Search results for RNA - 806 results

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Valid biomarker signatures from liquid biopsies – how to standardise NGS

6 December 2016 | By Benedikt Kirchner (TUM School of Life Sciences and Ludwig-Maximilians-University Munich), Dominik Buschmann (TUM School of Life Sciences and Ludwig-Maximilians-University Munich), Michael W. Pfaffl (TUM School of Life Sciences)

The advent of next-generation sequencing (NGS) techniques has revolutionised transcriptomics research and opened numerous avenues for scientific and clinical applications. While reverse transcriptase quantitative real-time polymerase chain reaction (RT-qPCR) is still considered the gold standard of gene expression analysis, its high throughput, single-nucleotide resolution and ever-plummeting costs have made NGS…

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How engineered RNA binding proteins delivered in vivo by gene therapy could treat myotonic dystrophy

13 July 2021 | By Dr Jim Burns (Locanabio)

In this article, Dr Jim Burns discusses promising pre-clinical results of how a new platform could treat the root cause of many devastating genetic diseases including myotonic dystrophy type 1.

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The therapeutic potential of RNA directed epigenetic regulation of transcription

10 May 2014 | By Kevin V. Morris (University of New South Wales / The Scripps Research Institute)

Developments over the past decade have demonstrated that non-coding RNAs can exert control of transcriptional gene expression. Recent advances in genome-wide studies have revealed an abundance of long non-coding RNAs (lncRNAs) in human cells, which are as numerous as protein-coding genes...

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The potential of epigenomic medicine in cardiology

22 June 2021 | By Professor John Giannios (Learna)

Advances in genomic medicine are playing an increasingly important role in the field of cardiology. Better analysis and understanding of patient genomic and epigenomic information can enable more personalised patient treatment and medical intervention. Here, Professor John Giannios considers the potential to use genomic medicine to prevent, monitor, diagnose and…

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Next-generation transcriptomic analysis in cancer vascular research

3 December 2015 | By Joseph Wragg (University of Birmingham), Roy Bicknell (University of Birmingham)

Over the past decade significant advances have been made in the fields of genomic and transcriptomic profiling, inspired by the advent of next-generation sequencing (NGS). Yet despite the considerable promise of these new technologies, uptake has been slow. The focus of this review is the use of next-generation transcriptomic analysis…

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RNA processing in health and disease: challenges and opportunities of the field

15 June 2023 | By Izzy Wood (Drug Target Review)

In this interview, Sam Hasson, Senior Director at Rgenta Therapeutics, shares his journey in drug discovery, from graduate school to industry, and his current work developing small molecule therapeutics to target RNA processing. He discusses the challenges and opportunities in the field of RNA-centric drug discovery and highlights the potential…

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NGS: enabling biomarker discovery at single-cell resolution

12 September 2018 | By Alka Saxena - National Institute for Health Research (NIHR) Guy’s and St Thomas’ Biomedical Research Centre

Investigations using Next-Generation Sequencing (NGS), once the domain of well-funded labs, have now become mainstream in the hunt for biomarkers for various disorders – ranging from breast and colon cancers to cardiomyopathies, diabetes, congenital cataracts, liver diseases and mitochondrial disorders. The NHS Executive (NHSE) has recently announced the use of…

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Combining deep computational learning and synthetic biology

3 December 2020 | By Victoria Rees (Drug Target Review)

Dr Diogo Camacho from the Wyss Institute at Harvard discusses new research into using machine learning algorithms to analyse RNA sequences and reveal potential drug targets.

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Promising new RNA editing technology could be used to treat genetic diseases

14 February 2022 | By Ria Kakkad (Drug Target Review)

New research by the University of California, San Diego could provide a much simpler way to repair disease-causing mutations in RNA.

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Inhibition of RNA-containing viruses by artificial RNases

16 June 2016 | By Dmitry Klinov (Federal Medical and Biological Agency of the Russian Federation), Elena Isaeva (D. I. Ivanovsky Institute of Virology), Ludmila Koroleva (Siberian branch of the Russian Academy of Sciences), Olga Morozova (D. I. Ivanovsky Institute of Virology and Federal Medical and Biological Agency of the Russian Federation), Vladimir Silnikov (Siberian branch of the Russian Academy of Sciences)

The toxicity and antiviral properties of 24 low-molecular-weight artificial RNases (artRNases) including peptides, peptidomimetics, N-alkyl-substituted 1,4-diazabicyclo[2.2.2]octane (DABCO) and a silver (I) complex with cystine were analysed for viruses containing single-stranded and double-stranded genomic RNA (the tick-borne encephalitis virus; TBEV and the influenza virus, respectively) in vitro and in vivo by…

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How RNA therapeutics can be used to treat retinitis pigmentosa

5 April 2021 | By Sahm Nasseri (PYC Therapeutics)

Sahm Nasseri discusses promising pre-clinical results of an RNA-based therapeutic developed to treat retinitis pigmentosa type 11.

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RNA structures of SARS-CoV-2 reveal potential drug targets

11 November 2020 | By Victoria Rees (Drug Target Review)

The SARS-CoV-2 RNA genome structure has been studied by researchers who identified several potential drug targets.

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CRISPR RNA-targeted genetic screen could be used for COVID-19 therapy

18 March 2020 | By Hannah Balfour (Drug Target Review)

A new Cas13 RNA screen has been used to establish guide RNAs for the COVID-19 coronavirus and human RNA segments which could be used in vaccines, therapeutics and diagnostics.

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CRISPR engineered to edit single RNA letters

26 October 2017 | By Dr Zara Kassam (Drug Target Review)

New 'REPAIR' system edits RNA, rather than DNA, without permanently affecting the genome...

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Understanding Z-RNA structure could provide new treatments

3 November 2023 | By Drug Target Review

A $1.2 million grant has been given to observe how Z-RNA is formed and explore its benefits for various diseases.