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Professor Alexander Makarov (Thermo Fisher Scientific)

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Advances in mass spectrometry: unlocking the potential of chemical crosslinking as a structural biology tool

16 December 2019 | By , , ,

Chemical crosslinking coupled with mass spectrometry (XL-MS) has been used for many years to study protein structure and function. However, recent advances in MS technology, as well as crosslinking reagents and data analysis tools, mean the technique has truly come of age. Here, Albert JR Heck, Alexander Makarov, Henning Urlaub…