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AI-based screening method could boost speed of new drug discovery
Using an AI algorithm that models drug and target protein interactions, researchers achieved up to 97 percent accuracy in identifying promising drug candidates.
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Screening
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Application note: Flow cytometry platform
Compendium of iQue® advanced flow cytometry platform application posters: Antibody discovery and immuno-oncology.
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Application note: Fast-track antibody discovery: a high-throughput method for identifying and isolating rare secreting cells
Discover how picodroplet microfluidic technologies can identify and isolate 'hit' cells, quantify varying concentrations of antigen-specific antibodies and much more.
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Novel screening reveals drug candidates for Huntington’s disease
Researchers have developed a new method that enables high-throughput screening of Huntington’s disease organoids.
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A high-throughput macrodomain assay to identify coronavirus drugs
In the search for a rapid, easy way to identify drugs to fight SARS-CoV-2, researchers from across the US came together to develop and apply a high-throughput ADP-ribosylhydrolase assay, ADPr-Glo. Here, Dr Veronica Busa and Dr Anthony Leung from Johns Hopkins University describe the ADPr-Glo assay and how it can be…
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Building a powerful portfolio of sepsis biomarker signatures for therapeutic clinical trials
In this Q&A, Immunexpress Chief Executive Officer Dr Rolland Carlson and Chief Scientific Officer Dr Richard Brandon discuss key aspects for molecular diagnostic discovery and development platforms, including how to best leverage microarray and next-generation sequencing (NGS) tools.
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Application note: Studying Avi-tag protein interactions by SPR
Learn how R&D Systems™ Avi-tag biotinylated proteins can be used as an alternative to amine biotin coupling in surface plasmon resonance experiments.
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High-throughput screening reveals compounds that inhibit SARS-CoV-2 replication
Researchers have used a high-throughput assay to screen for potential small molecule SARS-CoV-2 replication inhibitors.
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Cancer immunotherapy drug discovery outsourcing size to increase globally
A report has shown that the immuno-oncology drug discovery outsourcing market is set to be worth $2563 million by 2030.
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ebook: Binding kinetics in drug discovery
This ebook explores the role of binding kinetics in drug discovery, current methods for kinetic parameter analysis, novel approaches and applications.
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Screening reveals modulators of macrophage training and SARS CoV-2 infection
Researchers screened biologically active small molecules, finding several compounds with the ability to induce training effects on macrophages.
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Global high-content screening market set to be worth $2.52bn by 2030
A report has found that rapidly evolving R&D infrastructure will help to drive the high-content screening market forwards.
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Drug Target Review Assays ebook 2022
Included in this ebook are pieces on how an assay for the detection of sepsis was developed and a new high-throughput assay that could reveal new drugs to fight COVID-19.
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Drug Target Review – Issue 3 2022
In this issue are articles on synthetically engineered bacteria to deliver therapeutics, how single-molecule fluorescence resonance energy transfer was used to image GPCRs and a new assay to identify coronavirus drugs. Also included are pieces on vaccine development, monoclonal antibodies and neuroscience.
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Luminescent sensor could enable high-throughput screening in presence of fluorescence
A bioluminescence resonance energy transfer sensor has been developed to report changes in intracellular Ca2+ concentrations during screening.