Progressing actives from a high-throughput screen (HTS) of a target protein into suitable starting points for lead identification is fraught with pitfalls. The volume and quality of the HTS output is a function of the quality of the screening library, as well as specific properties of both the target and…
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12 December 2017 | By Joesph Zock (Product Managemenr at IntelliCyt)
One of the biggest challenges facing drug discovery across all therapeutic modalities (small molecule, biologics, and cellular) remains the balance between physiological relevance and throughput.
12 December 2017 | By PerkinElmer
In this application note, PerkinElmer demonstrate the utility of an AlphaLISA assay for screening biotherapeutic antibodies and compounds that block binding of human PD-1 and PD-L1.
11 December 2017 | By Drug Target Review
Drug discovery from concept to drug candidate has become a collective effort where multi-disciplinary project teams from CROs work with drug companies and academia to deliver clinical candidates, overcoming multi-factorial research obstacles along the way.
Declining R&D productivity is a key challenge in the pharmaceutical industry today.
8 December 2017 | By Drug Target Review
While attempting to position two chips on a microscope, an involuntary exhalation by scientist Greg Madejski caused them to adhere to great effect.
More than 90% of drugs that enter clinical evaluation fail to reach approval because of lack of efficacy or unexpected toxicity. This failure rate is in large part due to the use of overly simplistic in-vitro cell-based assays and animal models with limited predictive value...
Clinically-oriented phenotypic screening: understanding and exploiting the dynamic nature of the cancer cell phenotype
Understanding the cancer cell phenotype is central to both cancer diagnosis and treatment. Discrete molecular signatures among cancer phenotypes underpin patient stratification, while rapid methods for detailed phenotyping in the clinic (via liquid biopsies and tumour imaging) enable the delivery of personalised, effective precision medicines to the cancer patient...
6 December 2017 | By Drug Target Review
Recent study shows how a microscope using ultraviolet (UV) light to illuminate samples enables pathologists to assess high-resolution images of biopsies and other fresh tissue samples for disease, quickly and effectively.
2 December 2017 | By Dr Zara Kassam (Drug Target Review)
Blood sample, or liquid biopsy, can reveal which patients will respond to checkpoint inhibitor-based immunotherapies...
10 November 2017 | By SMi Group
SMi are delighted to have, Nagy Habib, Head of HPB Surgery, Imperial College London and Co-Founder, MiNA Therapeutics, as the Keynote Address for day 1 at RNA Therapeutics 2018!
9 November 2017 | By Dr Zara Kassam (Drug Target Review)
Scientists have shown that it is possible to incorporate DNA analysis into antenatal screening for three serious chromosome disorders including Down's syndrome...
8 November 2017 | By Dr Zara Kassam (Drug Target Review)
By surveying gene expression, researchers have created a reference atlas for understanding the biology of inflammatory bowel disease and food allergies, among other conditions...