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ebook: High-content analysis and infectious disease
Learn how you could use high-content analysis for functional & phenotypic assays in your infectious disease research or drug discovery.
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PerkinElmer
webinar
Establishing Alpha CETSA HT in primary screening
7 May 2020 | By PerkinElmer
High-throughput screening (HTS) cascades have evolved to ensure that high quality hits can be identified from large screening collections.
news
Label-free array system market to be worth $1,600 million by 2025, study finds
The global label-free array system market will grow at a compound annual growth rate of 7.44 percent in the forecast period, says new research.
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Webinar highlights: Harmonising drug-target binding data analytics on a single platform
Harmonising drug-target binding data analytics looks at building a single, integrated software platform for a future pharma research and development digital ecosystem. This webinar, sponsored by PerkinElmer, outlined the fundamentals of a design process where an experimental analytics data workflow was integrated into a more seamlessly interactive digital platform.
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Webinar preview: Compliance with data integrity and computerised system validations
Data integrity and computerised system validations (CSV) have become an area of increased scrutiny for regulatory agencies over the last several years. Understanding how the agencies view data integrity is critical for laboratories to maintain complete compliance.
webinar
Harmonising drug-target binding data analytics on a single platform
6 November 2018 | By PerkinElmer
This webinar outlined the fundamentals of a design process where an experimental analytics data workflow is being integrated into a more seamlessly interactive platform...
webinar
Compliance with data integrity and computerised system validations
30 October 2018 | By PerkinElmer
During this webinar, we investigated trends seen globally for data integrity violations and avenues for remediation.
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Assays In-Depth Focus 2018
This Assays In-Depth Focus looks at applications of high content screening in autophagy, and complex biology for the precision medicine era.
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Expert view: Assays to measure the potency of therapeutic antibodies used in combination with other drugs for Immuno‑Oncology treatments
Growing evidence reveals that using single immunotherapies to treat oncological disorders may lead to cancer-killing T-cell overdrive,initiating life-threatening autoimmune reactions including cytokinestorm; also known as hypercytokinemia or Cytokine Release Syndrome(CRS). Recently, checkpoint blockade using anti-programmed cell death1 (anti-PD-1) inhibitors became a prevalent approach for stimulatinganti-tumour immune system.
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Application Note: Evaluating the specificity and potency of PD-1 and PD-L1 blocking antibodies using AlphaLISA human and mouse PD-1/PD-L1 binding kits
Cancer immunotherapy utilises components of the immune system to treat cancer patients. These therapies are designed to work with a patient’s immune system to increase native anti-tumour responses. One type of immunotherapy relies on antibodies to bind to and inhibit the function of proteins expressed by the cancer cell...
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Application Note: ATPlite assay performance in human primary cells
ATPliteTM and ATPlite 1step are robust, rapid, high-throughput luminescence assays used to assess a compound’s druggability.
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Tech note: Detection of immune checkpoint markers in peripheral blood mononuclear cell lysates with AlphaLISA
Quickly and easily quantitate immune checkpoint markers using a fraction of the sample volume required by traditional ELISAs...
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Tech note: Fast, simple, homogeneous assays for characterisation of Fc receptor binding using AlphaLISA
AlphaLISA® provides a robust assay that facilitates the design and development of antibody therapeutics.
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Streamlining drug discovery assays for cancer and cardiovascular disease
For lead optimisation, target-based assays are still the most affordable means of rapidly performing fast iterations and remain core to screening. However, the desire for biological relevance is driving ongoing growth in cell-based assays.
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Technical note: 3D volumetric analysis of luminal spaces inside cysts or organoids
High-content assays using 3D objects, such as cysts or organoids, can be challenging from the perspectives of both image acquisition and image analysis.