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Potential target for type 1 diabetes treatment
Researchers have discovered a new pathway to the regeneration of insulin in pancreatic stem cells, findings that could move towards new therapies for type 1 and type 2 diabetes.
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Stem Cells
Stem cells are undifferentiated biological cells that can differentiate into specialised cells and can divide to produce more stem cells.
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Handbook: Western blot
Find western blot application protocols and troubleshooting tips for detecting proteins in this handbook.
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Video: Did you know that ddPCR technology offers lower variability for viral titer determination?
Droplet Digital PCR (ddPCR) offers greater accuracy and precision in quantifying viral titer in gene therapies.
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New immune targets to improve survival from sepsis
In a pre-clinical study, researchers from the US set out to develop a treatment for sepsis. Here, Daniel Morales-Mantilla, Dr Robin Parihar and Dr Katherine King, from Baylor College of Medicine, describe how they utilised haematopoietic stem and progenitor cell infusion to improve the survival of mice from sepsis.
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Using cortical spheroids to study endocannabinoids and autism spectrum disorder
The endocannabinoid system may play a role in the development of autism spectrum disorder and might be key to treating people with severe forms of the condition. In this commentary, Dr Karen Litwa, Assistant Professor at East Carolina University’s Brody School of Medicine, US explores how a bioelectronic assay is…
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Infographic: Detecting Mycoplasma contamination in your cell culture with confidence
This infographic will explore Mycoplasma contamination in cell cultures and the best technologies for detection.
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Product hub: A reproducible and scalable Huntington’s disease human cell model
Senior scientist Dr Tony Oosterveen discusses bit.bio’s new ioDisease Model portfolio, including new models for Huntington’s disease to help advance in vitro research and drug discovery.
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The promise of cell therapy: scaling up a new treatment paradigm for hearing loss
Expectations are growing worldwide for discoveries that will harness the potential of cell therapy, which has already brought breakthroughs in therapeutic areas where there is an unmet need, from oncology to ophthalmology and rare disease. In this article, Dr Terri Gaskell, Chief Technology Officer at Rinri Therapeutics, explores some of…
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Whitepaper: CAR T-Cell analysis with modular antibodies using SpyTag protein ligation
Here Bio-Rad presents the generation of specific anti-CAR T-cell antibodies to show how CAR T-cell analysis benefits from our modular antibody assembly technology using SpyTag-SpyCatcher protein ligation.
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Handbook: Flow cytometry
An easy-to-follow guide to flow cytometry that is well suited for researchers new to the technique, or experienced scientists looking for a refresher.
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Drug Target Review Cell & Gene Therapy ebook
This ebook features articles from gene therapy specialists that look at current platforms as well as the future of promising modalities for gene therapies. It also tackles novel stem cell technology considerations and gives insight into the careful balancing act between efficacy and safety in gene therapy.
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Drug Target Review – Issue 2 2022
In this issue are articles focusing on a novel stem cell therapy for hearing loss, how a non-linear chiroptical effect could aid drug discovery and the advantages of cryo-electron tomography for imaging research. Also included are pieces on gene therapy, spheroids and genomics.
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Immune protein may contribute to alcoholism relapse
Scientists have found that an immune protein, CSF1, may cause anxiety during alcohol withdrawal, therefore causing relapse.
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Podcast: Challenges for the bioanalysis of CAR-T Cells
Podcast discussion featuring CAR-T Cell therapy development and reviewing current challenges and future potentials for these cell therapies.
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New immune targets to improve survival from sepsis
References for ‘New immune targets to improve survival from sepsis’, in Drug Target Review Issue 2 2022.