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- March 23, 2020 at 3:56 pm #57964Victoria ReesKeymaster
Which drug target or development will be the most successful way of combatting COVID-19? Are there any repurposed drugs that will be more effective than a newly discovered one?March 30, 2020 at 6:11 pm #58879FrancescoGuest
I would focus on therapy of consequences of infection, more than on prevention or treatment of infection. It could be an important item,since a majority of patients have mild symptoms, but relatively few, still a most significant number of patients, would die. Most patients die because following viral pneumonia they would develop a “cytokine storm”, similar to those observed in other interstitial pneumonias of viral origin. A target should be, therefore, NFkB, a main transducer of cytokine response. In critically ill patients, therefore, off label use of a cheap and widely available drug, thalidomide, could be possibly indicated in emergency. Its peculiar toxicity is well known and manageable, in front of a dramatic number of people who are at risk of death. Of notice, pregnant women usually do not develop serious illnesses. Hope that this proposal and rationale would be somehow useful.