Sean Semple

Sean Semple, Vice President of Preclinical Research at Acuitas Therapeutics, has more than 30 years’ experience in the development of lipid nanoparticle therapeutics. As the inventor and pioneer of the ionisable lipid approach to formulate and enable nucleic acids in LNPs, Sean has led numerous first-in-class oligonucleotide–LNP and siRNA–LNP non-clinical programmes into clinical development. He has held positions of increasing responsibility at Arbutus Biopharma, Tekmira Pharmaceuticals and Inex Pharmaceuticals, and is actively engaged with Acuitas’ partners in several gene-editing clinical trials.