Drug Discovery News, Articles, Events

Making cell culture models more physiologically relevant

Robert Skolik explains how a galactose‑induced cellular phenotype is more reminiscent of a primary hepatocyte than glucose-induced, which may aid in the early detection of hepatotoxic compounds.

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Automating functional cell-based bioassays: assay reproducibility and performance for potency testing programmes

Join us live to discover how Eurofins DiscoverX’s functional, physiologically relevant, MOA-based assay platform accelerates discovery.

Latest Drug Discovery News

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New class of compounds found to block coronavirus reproduction

In cell cultures, a compound named STM2457 was shown to interfere with coronavirus replication, making it a potential treatment for SARS-CoV-2.

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Stem cells used to enhance immune response to HIV in primates

In non-human primates, researchers have found that mesenchymal stem cells were effective at strengthening the immune response to HIV.

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Researchers discover class of drugs that could treat mantle cell lymphoma

A screening campaign has revealed that small molecule inhibitors of the SOX 11 oncogene are toxic to mantle cell lymphoma in vitro.

Articles from Drug Target Review

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Transcriptional reprogramming rescues vascular fate of misidentified pluripotent cell‑derived epithelial…

By Dr Raphaël Lis (Weill Cornell Medicine)

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Drug development in stem cell-derived liver organoid models

By Dr Takanori Takebe (Cincinnati Children’s Hospital)

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Novel vectors for more efficient and less risky ocular gene…

By Professor Stylianos Michalakis (Ludwig Maximilian University)

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Using cholangiocyte organoids to regenerate human bile ducts

By Dr Fotios Sampaziotis (University of Cambridge)

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Covalent fragment screening in cell-based phenotypic models of disease: a…

By Dr Andrew Powell (GlaxoSmithKline), Dr David House (GlaxoSmithKline), Dr…

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Targeting phosphodiesterase 3A: discovery of a promising cancer therapy

By Dr Harri Sihto (University of Helsinki), Dr Katja Ivanitskiy…

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