Omics

Molecules associated with NMDAR may be involved in schizophrenia

18 January 2019 | By Drug Target Review

Genetic variants which prevent a neurotransmitter receptor from working properly have been implicated in the development of schizophrenia...

Scientists developed a new mouse model of Hirschsprung’s disease

17 January 2019 | By Drug Target Review

Researchers have developed the first viable mouse model of Hirschsprung’s disease and associated enterocolitis with a defect in GDNF/GFRa1/RET signalling...

GREB1 gene potential drug target for prostate cancer treatment

16 January 2019 | By Drug Target Review

Researchers in the US have discovered how a gene involved in regulating hormone receptors, GREB1, may contribute to drug resistance in some prostate cancer patients.

CRISPR repurposed to develop better antibiotics

14 January 2019 | By Iqra Farooq (Drug Target Review)

Mobile-CRISPRi could be used to guide gene expression, in turn control levels of proteins produced, enabling scientists to identify key antibiotic targets...

Whitepaper: The most important mouse in the world: the utility and applications of C57BL/6 models

10 January 2019 | By Taconic Biosciences

Learn everything you need to know about the most widely-used mouse in biomedical research with this free whitepaper.

Whitepaper: Application of CRISPR/Cas to the generation of genetically engineered mice

7 January 2019 | By Taconic Biosciences

Learn how the continued development of CRISPR gene editing technologies opens fresh possibilities for in vivo model design.

Taconic Biosciences

Proteomics: cracking the molecular mystery of diseases and therapeutics

10 December 2018 | By Anowarul Amin

In the wake of the human genome project, molecular biology and genetic technologies are tremendously integrating into biomedical research. Currently, PCR, qPCR, and sequencing are key tools in the clinical laboratory for the detection and characterisation of microorganisms and genetic disorders.

Expert view: Challenges in drug discovery screening

6 December 2018 | By Steven Jarvis (Scientific Director - Global Strategic Accounts at Merck)

The basic premise of drug discovery screening necessitates that the biological assays upon which it depends can be performed in a reproducible manner. In addition, the techniques employed must generate results that are biologically relevant and actionable.

Application Notes supplement 2018

4 December 2018 | By Drug Target Review

Researchers are always looking more effective and efficient ways of making their work more successful. In this supplement, some of our commercial partners share their data, detailing the application of their technology.

Mechanism could aid methods to combat immune attacks on the body

27 November 2018 | By Drug Target Review

Chemical changes on mRNA were found to control the production of a protein called interferon beta, which could give insights on tackling immune diseases...

Drug Target Review – Issue 4 2018

26 November 2018 | By Drug Target Review

In this issue: Omics-informed drug target discovery in combating emerging infectious diseases, measuring intracellular ATP levels to access compound-mediated cellular toxicity, and turning organoids into physiologically relevant high-content assays for drug discovery.

scRNA-seq technique improves efficiency and accuracy of single cell RNA sequencing

22 November 2018 | By Drug Target Review

Single nucleotide variations could be the key to better identification of tumour subpopulations...

Drug candidate offers hope of vocal improvement for ADNP syndrome

16 November 2018 | By Drug Target Review

Scientists have uncovered a promising drug candidate that appears to normalise the vocal communication mechanism deficiencies experienced in genetic disorder ADNP.

CRISPR used to prevent cancers tied to EBV and KSHV

13 November 2018 | By Drug Target Review

Researchers have discovered a possible path forward in preventing the development of cancers tied to two viruses, including the virus that causes infectious mononucleosis...