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10 January 2019 | By Taconic Biosciences
Learn everything you need to know about the most widely-used mouse in biomedical research with this free whitepaper.
7 January 2019 | By Taconic Biosciences
Learn how the continued development of CRISPR gene editing technologies opens fresh possibilities for in vivo model design.
21 December 2018 | By Sphere Fluidics Ltd.
Find out how to streamline Cell Line Development by identifying high-producing clones with monoclonality assurance in one day.
11 December 2018 | By SB Drug Discovery
SB Drug Discovery shows the validation of fluorescence and automated electrophysiology assays designed to assess agonists, antagonists and allosteric modulators of these receptors, culminating in a high-throughput electrophysiology assay suited to assessing multiple GABAA receptor subtypes on a single assay plate.
29 November 2018 | By Eppendorf
There is substantial interest in the scientific community in using human induced pluripotent stem cell (hiPSC)-derived neural cells to study basic mechanisms of brain development, neuronal function, and drug-induced effects. In vitro-generated brain organoids are promising models, because they show a remarkable degree of maturation and can be kept in…
29 November 2018 | By Thermo Fisher Scientfic
This technical note demonstrates the feasibility of using the Thermo Scientific™Fluoroskan™ or Fluoroskan FL instruments with the Invitrogen™ Quant-iT™ dsDNAhigh-sensitivity assays. Sensitive and specific quantification of double-stranded DNA is carried out in microplate format. This is part of a series of technical notes aiming to help customers choose the best…
29 November 2018 | By Fan Zhang, Sean McCarthy, Zoe Zhang
Development and production of biopharmaceuticals is complex. Even minor impurities, or changes in attributes such as glycosylation or charge heterogeneity, can have a profound impact on the safety and efficacy of the final product. Traditionally, multiple analytical techniques have been required to assess the full range of biopharmaceutical product attributes.…
29 November 2018 | By Thermo Fisher Scientfic
Every day scientists are working to discover and develop new therapies and treatments to change the lives of patients suffering from serious and debilitating illnesses. Amgen Inc. has made it a priority to unlock the potential of biology to discover, develop, manufacture, and deliver innovative therapeutics to patients.
29 November 2018 | By IntelliCyt Corporation
With breakthroughs in molecular engineering and antibody humanisation, monoclonal antibodies (mAb) are one of the fastest-growing classes of biopharmaceuticals for multiple clinical indications including cancer, cardiovascular disease, autoimmune disorders and infectious disease. Most therapeutic antibody candidates are initially generated using hybridoma technology or primary B-cell screening after antigen immunisation.
29 November 2018 | By Thermo Fisher Scientfic
Circulating cell-free DNA (cfDNA) has been shown to have potential as a noninvasive substrate for the detection and monitoring of tumour cells. As circulating tumour DNA is often present at low frequencies within cfDNA, targeted sequencing is an optimal tool for mutation detection.
29 November 2018 | By IDBS
Many bioanalytical labs work with a crowded and siloed set of systems and processes. From part electronic to part paper-based workflows to standalone point-solutions, the result is a lack of insight into data and slower reporting and results handling.
29 November 2018 | By Brian P. Dranka, George W. Rogers, Sarah E. Burroughs
Drug target identification has a key role in the drug discovery value chain. A critical step in the development of pharmaceuticals is identifying the direct targets of potential drug candidates as well as distinguishing any secondary or off-target effects...
29 November 2018 | By Christophe Jung, Peter Bandilla, Ulrich Unnerstall, Ulrike Gaul, Zhan Qi
Reporter gene assays have greatly helped our understanding of gene regulation and signal transduction in vitro and in vivo.
21 November 2018 | By BMG Labtech GmbH
YEATS domains are epigenetic regulators and are recognised as readers of histone post-translational modifications (HPTM) alongside bromodomains, PHD fingers, and others.
16 November 2018 | By BMG Labtech GmbH
This application note highlights the direct optic bottom reading performance of the BMG LABTECH microplate readers in two different cell-based fluorescence intensity assays from Invitrogen.
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