Learn how fragment-based drug discovery improves hit rates and delivers higher-value targets using various biophysical methods.
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Learn why researchers turned to biophysical methods to expose the molecular mechanisms of neurodegenerative diseases.
The identification and validation of novel drug targets is a challenging process for drug discovery programmes.
Application note: High-throughput sialylation screening in combination with titer monitoring for expediting clone selection in cell-line development
Glycosylation is one of the most important post-translational modifications when developing new biologics. It has a considerable impact on product performance and variability and is therefore a critical quality attribute (CQA), influencing product safety and efficacy.
29 May 2020 | By Fluidic Analytics
Styrene–maleic acid (SMA) copolymers have become popular tools used in membraneprotein research as they can extract both lipids and membrane proteins from cellular membranes while preserving the bilayer structure of the membrane in so-called nanodiscs.
Application note: Improvement of bovine parainfluenza 3 virus production yields and capacities using the Corning® HYPERFlask® cell culture vessel
Parainfluenza 3 (PI3V) is a virus that causes respiratory diseases in calves, from the common cold to advanced pneumonia.
Application note: Screening for optimal association and dissociation rates of ligands using a live cell binding assay
Potential drugs not only need to bind to their targets, they also need to remain bound for a specific amount of time in order to work efficiently.
Learn practical tips from eight Principal Investigators about how to start your own lab.
Learn how you could use high-content analysis for functional & phenotypic assays in your infectious disease research or drug discovery.
Advances in technology, such as the development of connected lab instruments, can integrate into workflows to help address reproducibility challenges.
No tumour prevails on its own. Rather, every tumour needs a community to thrive.
Application note: A rapid method to quantitatively screen bispecific antibodies using Protein A and HIS1K biosensors
Scientists at Celgene Corporation developed a screening process incorporating the Octet® HTX system to identify pools and clones with higher concentrations of bispecific antibodies. Higher throughput was achieved from the multiple simultaneous measures possible on the Octet system and rapid assay times, such as binding optimisation in only 10 minutes.…
Flow cytometry is a powerful, high-throughput technology that is used to characterise suspensions of single cells or particles.
Connected lab tools that digitally record each step researchers make, like Gilson’s TRACKMAN® Connected, help create traceable, centralised data.
Wnt proteins have been extremely difficult to purify in an active state due to their hydrophobic nature arising from post translational lipid modifications.