news
Screening platform reveals compounds that protect neuronal mitochondria
Researchers have developed a screening system and identified a set of compounds that protect neuronal mitochondria in mice.
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Origins and potential therapies for a neurodegenerative disorder found
Various potential therapeutic opportunities to treat spinocerebellar ataxia type 7 (SCA7) have been discovered in a new study into the neurodegenerative disorder.
news
Assay for reading six molecular pathways simultaneously developed
Researchers have developed a luciferase assay that can be used to monitor the effects of treatments on six different molecular targets at once.
article
Transitioning novel peptide hits into lead compounds
Unlike synthetic compound libraries, natural product hits must be identified and characterised, as the molecule is often unknown. Venom peptides are often inherently stable due to cysteine knots whereas other peptides may not be. Steve and Carol Trim discuss the challenges of the hit-to-lead journey with these non-standard hits.
article
Hit-to-lead in neglected diseases – it’s a numbers game
The hit-to-lead journey can be a long endeavour, with many failures along the way. Nikki Withers spoke with DNDi ’s Discovery Director Dr Charles Mowbray to hear how the organisation is working to identify new leads with activity in animal models of neglected tropical diseases and the potential for further…
article
Hit-To-Lead In-Depth Focus 2019
This in-depth focus features articles on identifying new leads for neglected tropical diseases and how to develop novel peptide hits into lead compounds.
article
Drug Target Review – Issue 4 2019
This issue includes a discussion on the future of high-throughput screening through collaboration, an analysis of mass spectrometry as a structural biology tool and an exploration of the challenges of hit-to-lead when researching tropical diseases. Also in the issue are articles on immuno-oncology and assays.
news
New screening method identifies potential compounds to combat cancer
The new screening technique may enable development of novel combination-immunotherapy regimens against cancers and persistent infections.
news
Novel peptide could lead to antibiotic for drug-resistant bacteria
A novel peptide has been discovered that attacks gram negative bacteria at a previously unknown site of action which presents a promising lead substance for the development of a new antibiotic.
video
Video: Large-scale hiPSC-based drug development
From small-scale stem cell production to large-scale hiPSC-based drug development: The flexibility of stirred-tank bioreactors.
whitepaper
Application note: Automated NGS library preparation on CyBio FeliX
The CyBio FeliX pipetting system was used to perform all liquid handling steps of the library preparation workflow for personal genome analysis.
whitepaper
Application note: qPCR to Measure Minute Volumes in High Throughput
Improve the reproducibility of the real-time results in 384 well format with the application of a qPCR using a pipetting robot & standardized sample setup.
news
Novel metabolic-focused high-throughput screening method developed
Researchers have created a new high-throughput screening system which could identify new drugs by focusing on nucleotide metabolism.
whitepaper
Application note: Using SYPRO® Orange to Detect Protein Melting Temps
Investigation of thermal protein stability in high throughput using the application of thermal shift assay using SYPRO ® Orange in 96 well format.
whitepaper
Application note: Detection of Mastitis Pathogens in Raw Milk
Detection of four pathogens of mastitis diseases using qTOWER³ in combination with extraction and detection systems for DNA diagnostics.