A new 'optochemogenetics' research approach from scientists at the Emory University School of Medicine could aid in helping stroke victims.
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Pharmaceutical company, Sanofi, will eliminate jobs in France and Germany and end new in-house cardiology research programmes.
Redundancies have been discovered in the biochemical signalling pathways of immune cells which could impact cancer immunotherapy.
A new study has identified antibodies that may hold the key to creating the first effective vaccine against malaria infection in the blood.
Progressing drug discovery projects to a stage that attracts commercial interest is a challenging endeavour, evidenced by the fact that only a small proportion of drug discovery projects are successfully progressed to such a stage. A major cause of this is the lack of comprehensive profiling of compounds prior to…
Scientists have discovered a cell intrinsic tumour suppressor role of the innate immune sensor Toll-like receptor 2.
A new study shows that the growth rate of a tumour does not depend solely on how quickly the cancer cells can divide.
New findings could be translated into the development of novel treatments for patients with optic neuropathies.
Findings from a recent study could lead to the development of therapeutic approaches against influenza A viruses.
Researchers have shown how skin vaccinations could be used as a vaccination strategy for sexually transmitted infections (STIs).
Treatments for chronic inflammatory diseases are one step closer as a new study discovers a way to stop inflammation in its tracks.
Researchers have finally shown how inflammation caused by H. pylori infection causes the proliferation of gastric epithelial stem cells, leading to gastric tumours.
Flow chemistry is on the rise thanks to the commercial availability of benchtop continuous flow systems that has driven widespread adoption of the technique across a broad range of applications in both academia and industry. In particular, flow chemistry is delivering significant benefits in the area of drug discovery and…
The landscape of cancer treatment has changed dramatically in the last seven years, beginning with the approval of Ipilmumab in 2011, the first immunotherapy drug. Efforts to unsheathe the tumour cells of their protective microenvironment and expose them to an active immune response have delivered several monoclonal antibodies (mAbs) that…
The importance of characterising chemical starting points of drugs using appropriate in vitro ADME-toxicity assays
Over the past 30 years, one strategy the pharmaceutical industry has adopted in the drug discovery process has been to “fail early, fail often”.1,2 As most molecules in the early stages of drug discovery will have sub-optimal characteristics, significant modification is necessary to improve their properties.