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20 September 2018 | By Iqra Farooq (Drug Target Review)
Women with ovarian cancer could in future benefit from a combined therapy using PD-1 and CTLA-4 as shown through the results of this Phase II trial...
19 September 2018 | By Drug Target Review
Researchers have found a surprising use for EGCG: sneaking therapeutic RNAs into cells...
18 September 2018 | By Iqra Farooq (Drug Target Review)
Researchers from Imperial College London have identified 6 compounds from almost 70,000 that could help to eradicate malaria...
13 September 2018 | By Dr Tim Brears - Chief Executive Officer - Evonetix
Synthetic biology is broadly defined as the design and construction of novel artificial biological pathways, organisms or devices; or the redesign of existing natural biological systems.1 It brings together a range of disciplines and skills, from biology and chemistry to computing, bioinformatics and engineering.
10 September 2018 | By Drug Target Review
Developing an HIV vaccine focuses on discovering the factors responsible for the production of antibodies that neutralise almost all known virus strains...
7 September 2018 | By Conor Fitzpatrick
Flow cytometry has played a key role in drug development, largely due to its ability to measure up to twenty parameters on single cells or particles suspended in a fluid stream. Typically, cells are labelled with fluorescent markers and passed through a series of lasers, after which the resultant fluorescent…
6 September 2018 | By Drug Target Review
This Assays In-Depth Focus looks at applications of high content screening in autophagy, and complex biology for the precision medicine era.
5 September 2018 | By Steven G Jarvis (Head of Pharma & Biotech Segment Strategy - MilliporeSigma)
Assessing targets that are unable – or rather, extremely difficult – to reach pharmacologically, has prevented researchers from achieving desired clinical successes, most notably in the realm of cancer research. However, many advances are being made to shedlight on these difficult yet desirable target areas.
4 September 2018 | By Ole Pless, Saba Ezazi Erdi, Sheraz Gul
Autophagy is an important process to maintain cellular homeostasis and function.1 Basal levels of autophagy are essential for most cells to remove unwanted protein aggregates and damaged organelles in order to prevent diseases.2 However, sometimes cells are unable to maintain physiological stability as a consequence of altered autophagy, which leads…
3 September 2018 | By Iqra Farooq (Drug Target Review)
The neutrophil nanosponges can absorb and neutralise cytokines which play a role in the development of rheumatoid arthritis...
3 September 2018 | By Drug Target Review
In this issue: pharmacological targeting of mitochondrial dysfunction in Parkinson’s disease, the evolving role of three dimensional in-vitro cell culture techniques in drug discovery, and NGS: hunting mysterious ‘Dark Matter Genome’ towards rewriting the rules of genetic diseases.
3 September 2018 | By Dr Zara Kassam (Drug Target Review)
Researchers have found that a single dose of cannabidiol in rats with symptoms of depression was highly effective at eliminating symptoms...
31 August 2018 | By Iqra Farooq (Drug Target Review)
Venoms are continually being researched as potential chemicals for medicinal therapeutics to treat autoimmune diseases and diabetes...
30 August 2018 | By Iqra Farooq (Drug Target Review)
Scientists have discovered the chemical compound AT-121, which could soon lead to a painkiller stronger than morphine, but without the side effects...
30 August 2018 | By Dr Zara Kassam (Drug Target Review)
Researchers have identified a potential treatment that will be a foundation for developing drugs for various genetic disorders...
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