Producing vaccines without the use of chemicals
15 January 2019 | By Drug Target Review
Innovative new technology will use electron beams to produce inactivated vaccines quickly, reproducibly and without the use of chemicals...
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Hit-to-Lead
Small molecules could have big benefits in the battle against cancers
15 January 2019 | By Douglas J. Swirsky
Immunotherapy and targeted treatments, including targeted chemotherapy, continue to show great potential in cancer care. Future steps in their development will involve improving their ability to treat a wider range of cancers and a broader cross-section of the patient population, especially those for whom current treatments have shown limited efficacy...
Inhalable mRNA could treat lung disease
7 January 2019 | By Iqra Farooq (Drug Target Review)
An inhalable mix of a polymer and mRNA molecules, used to produce luciferase, could be the method of treating lung diseases in the future...
Triple-negative breast cancer could be treated using experimental treatment
4 January 2019 | By Drug Target Review
A mouse study has revealed that triple-negative breast cancer could be tackled by using recombinant Tinagl1 in therapy targeting signalling pathways...
The mysterious functions of the PCSK9 protein
3 January 2019 | By Drug Target Review
Researchers have described the methods used to build a model of the 'druggable' PCSK9 inhibitor and detailed how it works...
Potential drug targets found by muting large silent genes
2 January 2019 | By Iqra Farooq (Drug Target Review)
Streptomyces bacteria has been used to identify compounds that could lead to the production of drugs to treat various conditions...
Human antibody discovery could save lives from fungal killer
12 December 2018 | By Drug Target Review
Novel therapy uses antibodies cloned from patients who have recovered from an infection caused by the fungus Candida…
Compounds in coffee may fight Parkinson’s
11 December 2018 | By Drug Target Review
Caffeine plus another compound in coffee beans' waxy coating may protect against brain degeneration...
Webinar highlights: Harmonising drug-target binding data analytics on a single platform
7 December 2018 | By PerkinElmer
Harmonising drug-target binding data analytics looks at building a single, integrated software platform for a future pharma research and development digital ecosystem. This webinar, sponsored by PerkinElmer, outlined the fundamentals of a design process where an experimental analytics data workflow was integrated into a more seamlessly interactive digital platform.
Expert view: Challenges in drug discovery screening
6 December 2018 | By Steven Jarvis (Scientific Director - Global Strategic Accounts at Merck)
The basic premise of drug discovery screening necessitates that the biological assays upon which it depends can be performed in a reproducible manner. In addition, the techniques employed must generate results that are biologically relevant and actionable.
PAINS management: an open source model to eliminate nuisance compounds
4 December 2018 | By Stephen J. Capuzzi and David C. Morris (Eshelman School of Pharmacy - University of North Carolina Chapel Hill)
High-throughput screening (HTS) technologies have enabled the routine testing of millions of compounds towards the identification of novel ‘hit’ molecules for therapeutic targets. Oftentimes in this drug discovery process, however, compounds that show promising activity in primary screens show no activity during subsequent hit qualification or progression efforts.
Application Notes supplement 2018
4 December 2018 | By Drug Target Review
Researchers are always looking more effective and efficient ways of making their work more successful. In this supplement, some of our commercial partners share their data, detailing the application of their technology.
Hit-to-Lead In-Depth Focus 2018
4 December 2018 | By Drug Target Review
This In-Depth Focus examines our understanding of the comprehensive and complex innate immune system, to develop novel treatments and an open source model to eliminate nuisance compounds
Targeting innate immunity to treat disease: potential therapeutic applications
3 December 2018 | By Christopher Schaber - PhD, Oreola Donini - PhD - Chief Scientific Officer, President - Chief Executive Officer, Richard Straube - MD - Chief Medical Officer
Despite being one of the more ancient aspects of immunity, therapeutic modulation of the innate immune system has rarely been attempted. Innate immunity is intrinsically linked to the generation of inflammation – necessary for signalling to the adaptive immune system but often self-perpetuating and over-exaggerated, leading to deleterious effects, including…
Application note: Direct measurements of cellular metabolism for identification of mitochondrial drug targets
29 November 2018 | By Brian P. Dranka, George W. Rogers, Sarah E. Burroughs
Drug target identification has a key role in the drug discovery value chain. A critical step in the development of pharmaceuticals is identifying the direct targets of potential drug candidates as well as distinguishing any secondary or off-target effects...
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