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Light-stimulated brain cells could aid in stroke recovery research
A new 'optochemogenetics' research approach from scientists at the Emory University School of Medicine could aid in helping stroke victims.
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Job cuts limit cardiovascular and diabetes research and development
Pharmaceutical company, Sanofi, will eliminate jobs in France and Germany and end new in-house cardiology research programmes.
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Scientists have discovered important redundancies in T cells
Redundancies have been discovered in the biochemical signalling pathways of immune cells which could impact cancer immunotherapy.
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Protective antibodies identified that could be key to malaria vaccine
A new study has identified antibodies that may hold the key to creating the first effective vaccine against malaria infection in the blood.
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Screening and beyond in drug discovery
Progressing drug discovery projects to a stage that attracts commercial interest is a challenging endeavour, evidenced by the fact that only a small proportion of drug discovery projects are successfully progressed to such a stage. A major cause of this is the lack of comprehensive profiling of compounds prior to…
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New link shown between innate immune sensing and cellular senescence
Scientists have discovered a cell intrinsic tumour suppressor role of the innate immune sensor Toll-like receptor 2.
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Study shows that immune cells determine growth of certain tumours
A new study shows that the growth rate of a tumour does not depend solely on how quickly the cancer cells can divide.
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Protein phosphorylation inhibition promotes optic nerve regeneration
New findings could be translated into the development of novel treatments for patients with optic neuropathies.
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In-depth research maps virulence factor of the influenza A virus in real time
Findings from a recent study could lead to the development of therapeutic approaches against influenza A viruses.
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Novel findings could improve vaccinations against STIs
Researchers have shown how skin vaccinations could be used as a vaccination strategy for sexually transmitted infections (STIs).
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Researchers take a leap forward for new anti-inflammatory drugs
Treatments for chronic inflammatory diseases are one step closer as a new study discovers a way to stop inflammation in its tracks.
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New study finally explains the link between inflammation and gastric cancer
Researchers have finally shown how inflammation caused by H. pylori infection causes the proliferation of gastric epithelial stem cells, leading to gastric tumours.
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Transforming drug discovery, development and delivery with flow chemistry
Flow chemistry is on the rise thanks to the commercial availability of benchtop continuous flow systems that has driven widespread adoption of the technique across a broad range of applications in both academia and industry. In particular, flow chemistry is delivering significant benefits in the area of drug discovery and…
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Kick-starting the immune response – the shifting landscape of immuno-oncology
The landscape of cancer treatment has changed dramatically in the last seven years, beginning with the approval of Ipilmumab in 2011, the first immunotherapy drug. Efforts to unsheathe the tumour cells of their protective microenvironment and expose them to an active immune response have delivered several monoclonal antibodies (mAbs) that…
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The importance of characterising chemical starting points of drugs using appropriate in vitro ADME-toxicity assays
Over the past 30 years, one strategy the pharmaceutical industry has adopted in the drug discovery process has been to “fail early, fail often”.1,2 As most molecules in the early stages of drug discovery will have sub-optimal characteristics, significant modification is necessary to improve their properties.
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