Establishing Alpha CETSA HT in primary screening
23 June 2020 By PerkinElmer
High-throughput screening (HTS) cascades have evolved to ensure that high quality hits can be identified from large screening collections.
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2020: Reset your expectation for surface plasmon resonance (SPR)
ON-DEMAND By Bruker Daltonics
Register for our latest webinar supported by Bruker Daltonics to get an overview of the SPR user and application landscape in 2020. During the one-hour session, you will learn about the latest software tools for Bruker’s SPR instrumentation and explore high-throughput screening strategies enabled by the Bruker SPR ecosystem.
New horizons in small molecule solubility screening
ON-DEMAND By Halo Labs
Aqueous solubility of small molecule compounds is an essential parameter during the hit-to-lead stage of drug discovery as well as lead optimization and formulation. Low solubility can result in misleading ADMET/DMPK analyses if some fraction of a compound precipitates. Watch on-demand to find out more!
Measuring the affinity of challenging protein targets
ON-DEMAND By Fluidic Analytics
Join us as we discuss the latest data from the literature and application studies where diffusional sizing (MDS) is used to assess a variety of protein interactions – even of difficult targets.
A high-throughput approach to developing T-cell immunotherapies
ON-DEMAND By Sartorius
Join us as we discuss the promises and pitfalls associated with developing individualised antigen-specific T-cell therapy products for clinical use.
Phenotypic screening using iPSC-based human disease biology
ON-DEMAND By Tecan and Ncardia
Ncardia, will discuss the application of human iPSC-derived cell-based assays and high throughput screening for drug discovery and development.
Compliance with data integrity and computerised system validations
ON-DEMAND By PerkinElmer
During this webinar, we investigated trends seen globally for data integrity violations and avenues for remediation.
Harmonising drug-target binding data analytics on a single platform
ON-DEMAND By PerkinElmer
This webinar outlined the fundamentals of a design process where an experimental analytics data workflow is being integrated into a more seamlessly interactive platform...
Cell-based and biochemical high-throughput screening in 1536-well plates
ON-DEMAND By BMG Labtech GmbH
In this webinar, we presented two examples of HTS in 1536-well plates, a screen for protein-protein interactions and a cell-based luciferase reporter assay.
Integrated fragment-based approach reveals enzymatic inhibitors with potential therapeutic application
ON-DEMAND By NanoTemper Technologies
In this webinar, speakers presented results of integrated fragment-based approaches that have led to the discovery of the first ligands of IDO1 that are able to modulate non-catalytic signalling functions of the enzyme...
Recent advances in diagnostics and treatments – from small molecules to cellular therapies
ON-DEMAND By Bio-Techne
With recent advances in medicine, cellular therapies are one step closer to becoming a reality where re-programmed cells, tissues and organs can be used as therapeutic agents. This webinar discussed the journey of medical treatments from small molecule to cellular therapies...
Using bioactivity profiling to support the progression of phenotypic hits
ON-DEMAND By Eurofins Pharma Discovery Services
In this webinar, we discussed a recent case study where a phenotypic screen was performed using poly I:C / IL-4 stimulated human bronchial epithelial cells. This resulted in the identification of 7 representative hits which provided starting points for new drug discovery opportunities.
High throughput screening for deep mining of antibody repertoires, Dr. Stefan Moese, Novartis, Switzerland
ON-DEMAND By Beckman Coulter
In this webinar you learn about a high throughput screening approach for mining of antibody repertoires in the context of biologics drug discovery.
Automated assessment of Liver and Cardiac toxicities in lead optimisation, using biochemical and human iPS cell assays
ON-DEMAND By TECAN
ABOUT THIS WEBINAR: In this two-part webinar, both automation of P450 (CYP) assays and the automatisation of cellular differentiation processes and compound testing using human induced pluripotent stem cells based assays was covered. Metabolism of drugs is a key factor in compound toxicity, and automated assays which monitor inhibition or…
Transforming translational research: CANscriptTM – A better predictive model for oncology
ON-DEMAND By Mitra Biotech
In this webinar, speaker Mark Paris, PhD discussed a recent study evaluating a cohort of HNSCC patient tumours treated with anti-PD1 using CANscript TM;. He also be reviewed the results of this study as a means of investigating predictors of clinical response and identifying mechanisms of resistance.