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The mast cell receptor MrgX2 and drug-induced anaphylaxis

ON-DEMAND By DiscoverX

The goal of this webinar is to illustrate how knowledge of MrgX2 activity across a panel of mammalian species can be integrated into drug development to influence choice of compound, species model and dosing regimen...

Cognitive Phenotypes in MS Mouse Models

ON-DEMAND By Charles River Laboratories

40-65% of MS patients have cognitive impairment and touchscreen testing in animal models is a new method to test cognitive issues in MS animal models...

Designing a Novel Cancer Drug: From Hit ID to Candidate

ON-DEMAND By Charles River

Discover how their multidisciplinary approach to hit ID, design and synthesis of novel chemical templates and development of targeted in vitro and in vivo assays resulted in the nomination of the first development candidate in just over two years...

Acute and inflammatory in vivo pain models

ON-DEMAND By Charles River

This webinar discusses our newly validated acute and inflammatory in vivo pain models, including information on how they were validated and how they can be used to test new pain treatment compounds, eventually leading to clinical translation...

Assessing neurological ion channel therapeutic and liability targets

ON-DEMAND By Charles River

This webinar explores neurological ion channel therapeutic and liability targets, featuring four subtypes of NMDA receptors. We also discuss the rationale and options for assessment of therapeutic compounds on panels of CNS ion channels for evaluating their risk for CNS liabilities...

Vertical integration of CRISPR/Cas9 in drug discovery

ON-DEMAND By Charles River

In this webinar, Charles River discuss the utilisation of CRISPR/Cas9 technology in drug discovery, with an emphasis on generation of in vitro models for high-throughput screening, and creating new mouse models...