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CRISPR used to treat Duchenne muscular dystrophy in mice
A study has shown that CRISPR can be used as a regenerative technique to treat Duchenne muscular dystrophy, which could be developed as a therapeutic option for humans.
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New mechanism of controlling fat production revealed
A new study has shown a new mechanism of controlling fat production in the body which could lead to new therapies to treat obesity.
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The elegant parallel of using CRISPR to understand disease mechanisms
CRISPR is the buzzword of the moment in the drug discovery industry – mainly due to its potential to correct disease-causing mutations. However, those using the technology need to be mindful that it is used responsibly, and possible risks are considered before use. Mark Behlke discusses the potential of CRISPR…
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Genomic medicine: cracking genomes to cure ‘incurable’ diseases
We are on the precipice of realising the true potential of genomics studies. Following completion of the Human Genome Project six years ago, huge strides have been made in understanding how the genome works, shedding light on disease pathogenesis and forging therapeutic efforts. In this article, Pushpanathan Muthuirulan explains how…
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Protein vital for enterovirus replication identified by study
Researchers have discovered a particular protein that is required for enterovirus replication and survival, presenting a therapeutic target.
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Expert view: Bio-Rad’s comprehensive genomics portfolio provides answers for every problem
Over three decades, Bio-Rad has built a broad genomics portfolio that touches on nearly every area of life science.
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Researchers improve CRISPR-Cas9 delivery efficiency
A team has used a lentiviral capsid-based bionanoparticle system to deliver CRISPR-Cas9 gene editing therapies, reducing undesired effects.
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Largest genome sequencing project launched in UK
The UK Biobank, the world’s largest genetics project, will sequence 500,000 genetic samples, which will be available to researchers everywhere.
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New gene therapy repairs neuron stroke damage in mice
Researchers have developed a new treatment method which turned glial cells into functioning neurons in mice after stroke.
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Nervous system discovery overturns previous theory
A ground-breaking nervous system discovery could be significant for the treatment of different neurological diseases.
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Genomics In-Depth Focus 2019
In this In-Depth Focus are articles on how genomics could revolutionise clinical treatment and an insight into the promise and pitfalls of using CRISPR.
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Genetic alterations linked to drug resistance revealed by liquid biopsies
A clinical study comparing liquid and tissue biopsies finds multiple resistance mechanisms in individual patients.
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Proteomic approach reveals metastatic melanoma resistance to therapies
A study has used a proteomic method to uncover why some melanoma tumours do not respond to immunotherapy, which could improve treatments.
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Drug Target Review Issue 3 2019
This issue includes an investigation into utilising recombinant antibodies for research, a highlight on protein design using computational methods and an examination of the advances in genomic medicine. Also in the issue are articles on next generation sequencing and upstream bioprocessing.
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Molecule discovered that regulates development of tumours
Researchers discover that a non-coding region of the genome originates a key molecule for the proliferation of cancerous tumours.