Drug Target Review – Publications

Drug Target Review Issue 2 2019

In this issue: novel approaches to produce radiolabelled antibodies, the use of CRISPR/Cas9 to accelerate the development of targeted therapies…

By Drug Target Review

Stem Cell In-Depth Focus 2019

This in-depth focus looks at the modification of stem cells to facilitate their efficient delivery to tumours, highlighting the new…

By Drug Target Review

Phenotypic profiling in drug discovery

Image-based phenotypic profiling of small molecules has been used for identification and characterisation of small molecules in drug discovery and…

By Ina Rothenaigner, Kamyar Hadian, Sean Lin

Imaging In-Depth Focus 2019

In this in-depth focus, the challenges of imaging are explored including how to develop high-resolution images. Also discussed are new…

By Drug Target Review

Screening In-Depth Focus 2019

This in-depth focus discusses screening and the uses of phenotypic profiling in drug discovery. Also examined is the role that…

By Drug Target Review

Expert view: High-content screening of complex physiologically-relevant cell models

High-content screening (HCS) approaches have become increasingly common in drug discovery with HCS technologies integrated across the drug discovery pipeline.…

By Andy Bashford PhD (European Imaging Application Scientist at Molecular Devices)

Application note: Detection of anti-drug antibody (ADA) using single molecule…

All biological therapeutics have the potential to induce an immunemediated response ranging from benign to severe adverse effects.

By Merck

CRISPR/Cas9-engineered cancer models: the next step forward for targeted cancer…

The advent of CRISPR/Cas9 gene editing, together with the plummeting cost of whole-genome sequencing, has cleared a path for the…

By Elizabeth Turner Gillies PhD, Fang Tian PhD

Radiochemistry and drug synthesis ‘in a flash’

Conventional methods for radiolabelling proteins are time consuming and difficult to automate. In this article, Jason P. Holland discusses how…

By Professor Dr Jason P. Holland - University of Zurich

Bringing native analysis into the fast-moving world of biologics

For the past thirty years, native mass spectrometry has grown in both scope and reach in labs across the globe…

By Christopher Nortcliffe - SCIEX

Screening and beyond in drug discovery

Progressing drug discovery projects to a stage that attracts commercial interest is a challenging endeavour, evidenced by the fact that…

By Sheraz Gul (Head of Drug Discovery at the Fraunhofer Institute for Molecular Biology and Applied Ecology)

Compound and fragment screening by native mass spectrometry

Native mass spectrometry has the potential to be a fast, simple, highly sensitive and automatable technique for compound screening in…

By Nicola Burgess-Brown, Rod Chalk

Image-based characterisation of cancer biotherapeutics

Scientists from LifeArc, an independent medical research charity in the UK, explain how they’re using the latest imaging technologies to…

By Laura Murch, Siobhán Leonard, Victoria Juskaite

Using stem cells to study the effects of cannabis on…

Thanks to new developments with induced pluripotent stem cells enabling generation of human neurons, scientists can more precisely analyse the…

By Thomas M. Durcan (McGill University), Trisha Rao (Montreal Neurological Institute)

Stem-cell technologies in immunotherapy

This article outlines the exciting developments that are taking place with immunotherapies and demonstrates how stem-cell technologies are proliferating the…

By Aparajita Dubey (Associate Scientific Manager at Biocon Biologics Limited)

High-content imaging: challenges of the 3D world

The potential of three-dimensional cell culture models is now well-recognised by scientists; however, there are still some challenges. Margaritha Mysior…

By Jeremy C. Simpson, Margaritha M. Mysior

Drug Target Review – Issue 4 2018

Drug Target Review – Issue 3 2018

Drug Target Review – Issue #2 2018

Drug Target Review – Issue #1 2018

Drug Target Review – Issue #4 2017

Drug Target Review – Issue #3 2017

Drug Target Review – Issue #2 2017

Drug Target Review – Issue #1 2017

Drug Target Review – Issue #4 2016

Drug Target Review – Issue #3 2016

Drug Target Review – Issue #2 2016

Drug Target Review – Issue #1 2016

Drug Target Review – Issue #4 2015

Drug Target Review – Issue #3 2015

Drug Target Review – Issue #2 2015

Lab Automation In-Depth Focus 2019

Informatics In-Depth Focus 2019

Assays In-Depth Focus 2019

Application Notes supplement 2018

Hit-to-Lead In-Depth Focus 2018

Screening In-Depth Focus 2018

Targets In-Depth Focus 2018

Upstream Bioprocessing In-Depth Focus 2018

Flow Cytometry In-Depth Focus 2018

Next-Generation Sequencing In-Depth Focus 2018

Assays In-Depth Focus 2018

Antibodies In-Depth Focus 2018

Screening In-Depth Focus 2018

Imaging In-Depth Focus 2018

Stem Cells In-Depth Focus 2018