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Screening

AI-driven automated chemistry as a tool to accelerate drug discovery

15 May 2019 | By Alexey Zakharov (National Center for Advancing Translational Sciences), Anton Simeonov (National Center for Advancing Translational Sciences)

Typically, early drug discovery campaigns start with the screening of chemical libraries to identify candidate chemotypes modulating a particular target and/or phenotype. Success of the primary screening depends on multiple factors related to both biology and chemistry. These include the target’s druggability, sensitivity and specificity of assay system, composition and…

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Application note: Tools and protocols for high-content imaging and analysis

14 May 2019 | By Thermo Fisher Scientific

Integrating hardware, software, and fluorescent labels for optimised HCA assay development.

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Application note: Laser technology for high-content imaging and analysis

14 May 2019 | By Thermo Fisher Scientific

Introducing the CellInsight CX7 LZR High-Content Analysis Platform - an updated version of our CellInsight CX7 instrument with advanced laser technology.

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Application note: Tools for 2D and 3D neuronal cell culture

14 May 2019 | By Thermo Fisher Scientific

From the B-27 Plus Neuronal Culture System to fluorescent probes for cell analysis. Publication history of B-27 supplements demonstrates that researchers are expanding its use, far beyond the long-term culture of rat hippocampal and cortical neurons.

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Novel drug discovery approach for personalised mental health treatment

10 May 2019 | By Drug Target Review

Researchers have developed a method that could drastically accelerate the search for new drugs to treat mental health disorders.

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Application note: Fuelling discovery with high-content imaging and analysis

10 May 2019 | By Thermo Fisher Scientific

HCA platforms automate image capture and data analysis, giving researchers the sample sizes and precise quantitation tools required for research.

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Screening for genes to improve protein production in yeast

2 May 2019 | By Drug Target Review

By silencing genes, researchers have increased the protein production in yeast, laying the grounds for engineering better yeast production hosts for industries producing biopharmaceutical proteins and industrial enzymes.

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Thermo Fisher Scientific - Phenotypic fingerprint of cellular function

HCA: Phenotypic fingerprint of cellular function

25 April 2019 | By ThermoFisher Scientific

High-content analysis app note: Phenotypic fingerprint of cellular function following gene editing by high-throughput imaging acquisition and analysis.

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HCA Application note: New way of measuring synaptic function

25 April 2019 | By ThermoFisher Scientific

High-content analysis: monitoring neurite morphology and synapse formation in primary neurons for neurotoxicity assessments and drug screening.

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Realising the promise of laboratory automation in biomedical research

11 April 2019 | By Pushpanathan Muthuirulan - Harvard University Cambridge

Automation offers a choice of powerful ways to design and execute high-quality laboratory research. The use of lab automation is now pervasive in biomedical labs, offering versatile platforms on which to perform an ever‑expanding array of tasks free of human errors, and a unique means to address the problems associated…

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Video: High content imaging to examine RNA in cancer cells

26 March 2019 | By Thermo Fisher Scientfic

Dr Kaylene Simpson, Peter MacCallum Cancer Center, describes their research using high content imaging to examine RNA in cancer cells.

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Video: 3D Culture Screening

26 March 2019 | By Thermo Fisher Scientfic

Michael Johnson and his team at Visikol talk about the work they do as a contract research organization on 3D Cell Cultures and how they utilize High-Content Analysis / Screening to generate insights.

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Assays In-Depth Focus 2019

14 March 2019 | By Drug Target Review

In this In-Depth Focus: the importance of characterising chemical starting points of drugs using appropriate in vitro ADME-toxicity assays, and why do we have no effective treatments for osteoarthritis?

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Non-invasive imaging for small airway lung disease

14 March 2019 | By Iqra Farooq (Drug Target Review)

A non-invasive method of imaging tiny bronchioles in the lungs of chronic obstructive pulmonary disease means patients could detect the disease earlier...

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Drug Target Review Issue 1 2019

14 March 2019 | By Drug Target Review

In this issue: AI-driven automated chemistry as a tool to accelerate drug discovery processes, the shifting landscape of immuno-oncology, and how lipid molecules provide an insight into biological research.