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Screening

Decoding cancer and inflammation: identifying selective inhibitors of SH2 domains

news

Small molecule inducers of trained immunity found

18 July 2024 | By Drug Target Review

Researchers screened over 2,000 small molecules and have now more than doubled the known compounds reported to induce trained immunity.

news

Discovery of a promising agonist adjuvant

9 July 2024 | By Drug Target Review

PVP-037, identified through a small molecule screen, induces a more durable and broader immune response to vaccines.

news

Assessing the risk of HCC with machine learning

24 June 2024 | By Drug Target Review

A novel screening tool may increase the five-year survival rate of hepatocellular carcinoma patients to 90 percent.

news

New AI process for accurate enrolment of patients to clinical trial

20 June 2024 | By Drug Target Review

The AI model screened the medical records of heart failure patients more accurately, quickly and cheaply, compared to study staff.

CRISPR Cas9 protein and DNA molecules, 3D gene therapy rendering

news

Cancer dependencies missed by some CRISPR guides

18 June 2024 | By Drug Target Review

Scientists discovered that, depending on germline variation, CRISPR-based experiments can result in false negatives.

whitepaper

Beyond the lab: screening

13 June 2024 | By Drug Target Review

This report provides exclusive access to content on innovative screening methods to improve detection and diagnosis of prevalent conditions like cancer and metabolic disease, with expert insights from leading professionals in the field.

Pregnant woman having her blood pressure taken

news

New first trimester screening algorithm for preeclampsia

10 May 2024 | By Drug Target Review

The screening model combines maternal history, ultrasound data and several tests for blood markers to enable personalised treatment.

Red blood cells flowing with too many white blood cells, indicating leukaemia

news

Associations of AML MRD levels with posttransplant clinical outcomes

9 May 2024 | By Drug Target Review

Patients with no detectable FLT3 mutations had the best outcomes after an allogenic hematopoietic cell transplant.

whitepaper

Poster: Assays for PRMT5, MLL4, METTL3/14, & NSP14

7 May 2024 | By BellBrook Labs

AptaFluor SAH: A Homogenous, Universal Assay for Histone, RNA, & DNA Methyltransferases. Case Study for PRMT5, MLL4, METTL3/14, & NSP14

article

Biomarker identification in the realm of rare diseases

7 May 2024 | By Dr Luke Piggott (Debiopharm), Ellen Capon (Drug Target Review)

In this Q&A, Debiopharm’s Principal Scientist Dr Luke Piggott defines the critical requirement of biomarkers for identifying rare diseases. He illuminates how AI-enhanced approaches are accelerating the drug discovery process, particularly regarding clinical trial enrolment, and the breakthroughs he hopes to see in the future.

news

New screening method for HPV-positive head and neck cancer

17 April 2024 | By Drug Target Review

A urine-based test that detects ctDNA from HPV-positive head and neck cancers could facilitate its early detection.

webinar

SAFIRE: AI predicted ADME for drug discovery: leveraging BioPrint

9 April 2024 | By Eurofins Discovery

Join Dr Carleton Sage to learn about predicting ADME properties as a key approach to improving the efficiency of small molecule drug discovery. AI ADME model development approaches and case studies within drug discovery projects will be discussed.

podcasts

CRISPR/Cas: exploring its impact on gene editing

8 March 2024 | By Drug Target Review, Molecular Devices

Tune in to this episode where we discuss the opportunities CRISPR/Cas technology offers to revolutionise drug discovery.

news

Novel tool to rapidly diagnose sarcoidosis

29 February 2024 | By Drug Target Review

A highly specific blood test can differentiate between patients with sarcoidosis and other respiratory conditions, like TB or lung cancer.

video

Video: Dianthus for identifying Microcycle® hits

22 February 2024 | By Dr. Reece Gardner

Hear how Dr. Reece Gardner from Curve Therapeutics uses the Dianthus instrument with Spectral Shift technology to validate Microcycle® hits.

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Screening