Typically, early drug discovery campaigns start with the screening of chemical libraries to identify candidate chemotypes modulating a particular target and/or phenotype. Success of the primary screening depends on multiple factors related to both biology and chemistry. These include the target’s druggability, sensitivity and specificity of assay system, composition and…
List view / Grid view
1 May 2019 | By Drug Target Review
Using a computational model, researchers were able to explain, predict, and manipulate the regeneration of a flatworm body.
29 March 2019 | By Drug Target Review
New method for computational mass spectrometry will speed up the discovery of natural products that could be used in medicines...
20 March 2019 | By Jeff Martin (Head of Compound Management - Alkermes Inc.)
Data drives drug discovery, yet it continues to be among the biggest challenges faced by the industry.1 Experiments are often not repeatable and data interpretation is subject to the biases and limitations of human beings.
18 March 2019 | By Drug Target Review
In this In-Depth Focus: realising the promise of laboratory automation in biomedical research, drug discovery from the age of information to the age of intelligence, and transforming drug discovery, development and delivery with flow chemistry.
14 March 2019 | By Iqra Farooq (Drug Target Review)
A machine-learning model has been developed to analyse protein sequences, giving an insight to their structure, function and phylogeny...
14 January 2019 | By Iqra Farooq (Drug Target Review)
A team of researchers have developed a computational bioinformatic method to predict and accurately locate enhancer regions on cell lines.
10 January 2019 | By Taconic Biosciences
Learn everything you need to know about the most widely-used mouse in biomedical research with this free whitepaper.
7 January 2019 | By Taconic Biosciences
Learn how the continued development of CRISPR gene editing technologies opens fresh possibilities for in vivo model design.
6 December 2018 | By Drug Target Review
Discovery based on analysis of tissue and saliva samples from oral cancer patients shows a correlation between a signature comprising three peptides and the presence of lymph node metastasis...