Using anti-malaria drugs to slow tumour growth
15 November 2018 | By Drug Target Review
Anti-malaria drugs, called chloroquines, target PPT1 from cancer cells, with researchers identifying how the drugs eliminate tumour growth in cancers...
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Precision neuroengineering reproduces brain-like functions in vitro
15 November 2018 | By Drug Target Review
Using precision engineering, researchers form Japan and Spain have collaborated to show brain-like functions in vitro to advance medical research...
Immune cell enzyme protects against tuberculosis
14 November 2018 | By Drug Target Review
Using lung tissue from humans and mouse models, researchers have found that HO-1 controls inflammation and protects against tuberculosis...
Combination of imaging techniques views retina in unprecedented detail
14 November 2018 | By Drug Target Review
Using two imaging techniques, adaptive optics and angiography, researchers have been able to view the retina in more detail than ever seen before...
Inhibiting USP13 destroys toxic clumps seen in Parkinson’s disease
14 November 2018 | By Drug Target Review
A team of neurologists have found that one reason Lewy bodies develop is that a molecule, USP13, has removed all the "tags" placed on alpha-synuclein that mark the protein for destruction...
Defective damage repair to DNA results in chromosome chaos
13 November 2018 | By Drug Target Review
German researchers have shown how defective damage repair to DNA results in chromothripsis - clustered chromosomal rearrangements...
Vaccinia virus hijacks cellular movements to spread
13 November 2018 | By Iqra Farooq (Drug Target Review)
To spread throughout the body, the vaccinia virus mimics the infected cells' own proteins enabling the cell to move around and spread...
CRISPR used to prevent cancers tied to EBV and KSHV
13 November 2018 | By Drug Target Review
Researchers have discovered a possible path forward in preventing the development of cancers tied to two viruses, including the virus that causes infectious mononucleosis...
RIP1 kinase as a therapeutic target for pancreatic cancer
12 November 2018 | By Iqra Farooq (Drug Target Review)
RIP1 has been shown to suppress the action of macrophages against the immune system and could be a potential therapeutic target for pancreatic cancer...
Swarm of exosomes protect against inhaled bacteria
12 November 2018 | By Iqra Farooq (Drug Target Review)
A swarm of billions of exosomes armed with proteins has been shown to assist in the fight against bacteria inhaled through the nose...
Mouse model for diabetic kidney disease suggests role for immune and inflammatory pathways
12 November 2018 | By Drug Target Review
Scientists have designed mice that successfully emulate a severe form of kidney damage in humans with diabetes, called diabetic nephropathy...
Magnetically controlled thrombolytic passed preclinical trials
9 November 2018 | By Iqra Farooq (Drug Target Review)
ITMO University scientists have used nanoparticles and magnetic waves to localise drug delivery in animal models, resulting in no side effects...
Drug repurposing using off patent drugs as antifungals
9 November 2018 | By Iqra Farooq (Drug Target Review)
Researchers have identified that Alexidine dihydrochloride can be used as a broad spectrum antifungal, and can also kill biofilms formed by these fungi...
Sensory neurons can be used to discover therapies for ALS
9 November 2018 | By Drug Target Review
New approach for testing for ALS may be useful to reverse debilitating disease...
High throughput screening for deep mining of antibody repertoires, Dr. Stefan Moese, Novartis, Switzerland
9 November 2018 | By Beckman Coulter
In this webinar you learn about a high throughput screening approach for mining of antibody repertoires in the context of biologics drug discovery.
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