Tissue-damaging protein channel identified
21 May 2019 | By Victoria Rees (Drug Target Review)
Researchers have discovered an acid-activated protein which could stop damage to tissues as a result of stroke and other health issues.
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Targets
New approach to targeting cancer cells developed by researchers
20 May 2019 | By Drug Target Review
A new approach to targeting cancer cells that circumvents a challenge faced by currently available cancer drugs has been developed.
Hidden influenza vulnerability found in human antibodies
17 May 2019 | By Drug Target Review
Scientists have discovered an unexpected weakness in the influenza virus protein.
AI-driven automated chemistry as a tool to accelerate drug discovery
15 May 2019 | By Alexey Zakharov (National Center for Advancing Translational Sciences), Anton Simeonov (National Center for Advancing Translational Sciences)
Typically, early drug discovery campaigns start with the screening of chemical libraries to identify candidate chemotypes modulating a particular target and/or phenotype. Success of the primary screening depends on multiple factors related to both biology and chemistry. These include the target’s druggability, sensitivity and specificity of assay system, composition and…
Application note: Tools and protocols for high-content imaging and analysis
14 May 2019 | By Thermo Fisher Scientific
Integrating hardware, software, and fluorescent labels for optimised HCA assay development.
Application note: Laser technology for high-content imaging and analysis
14 May 2019 | By Thermo Fisher Scientific
Introducing the CellInsight CX7 LZR High-Content Analysis Platform - an updated version of our CellInsight CX7 instrument with advanced laser technology.
Application note: Tools for 2D and 3D neuronal cell culture
14 May 2019 | By Thermo Fisher Scientific
From the B-27 Plus Neuronal Culture System to fluorescent probes for cell analysis. Publication history of B-27 supplements demonstrates that researchers are expanding its use, far beyond the long-term culture of rat hippocampal and cortical neurons.
Research identifies potential antiviral drug target
14 May 2019 | By Drug Target Review
A recent study has uncovered a key mechanism that allows some of the world's deadliest viruses to replicate.
Genomic analysis identifies potential prostate cancer targets
14 May 2019 | By Drug Target Review
In a recent study more than half of patients with advanced prostate cancers appear to be strong candidates for targeted cancer therapies.
DNA nanostructures for drug delivery remain a technical challenge
13 May 2019 | By Drug Target Review
Many studies indicating that DNA nanostructures can enter cells more readily than simple DNA strands are 'flawed'.
Application note: Fuelling discovery with high-content imaging and analysis
10 May 2019 | By Thermo Fisher Scientific
HCA platforms automate image capture and data analysis, giving researchers the sample sizes and precise quantitation tools required for research.
Key step in the transformation of B-cells to antibody-secreting cells described
8 May 2019 | By Drug Target Review
Scientists have detailed the role of a key controlling factor in the transformation of B-cells into antibody-secreting cells.
New approach shows regeneration of severely damaged lungs
7 May 2019 | By Drug Target Review
Researchers are first to demonstrate in a clinically relevant model that damaged lungs can be regenerated to meet transplantation criteria.
Magnetic microbots could help drug-delivery nanoparticles reach their targets
3 May 2019 | By Drug Target Review
MIT engineers have designed tiny robots that can help drug-delivery nanoparticles push their way out of the bloodstream and into a tumour or another disease site.
WINTHER trial yields promising results
2 May 2019 | By Drug Target Review
Comprehensive tumour profiling promises new therapeutic options for patients with advanced cancer.
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