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Structure of protein that triggers neurodegeneration isolated and analysed
Using X-ray crystallography and cryo-electron microscopy, researchers have elucidated the structure of the SARM1 protein, a target for neurodegeneration.
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Atomic force microscopy used to study endonuclease digestion of DNA nanostructures
A team of researchers have used microscopy techniques to monitor DNA degradation and anticancer drug release from nanostructures.
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SARS-CoV-2 model shows Spike protein co-operation
A new coarse-grained model of the complete SARS-CoV-2 virion has revealed potential new ways to combat the coronavirus.
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Computational method used to quantify tRNAs in any organism
Researchers have developed a new technique called mim-tRNAseq to measure, map and analyse tRNAs in cells, providing insight into disease.
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New fluorescence imaging method enables live RNA visualisation
A fluorescence imaging technique has allowed scientists to observe RNA in real time using single-molecule localisation microscopy.
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ebook: Revolutionise your lab with a cutting-edge bioprocess platform to drive quality and efficiency
With the right solution organisations can simplify their lab-based working, while ensuring the highest level of compliance with regulatory requirements.
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Researchers identify new therapeutic targets on SARS-CoV-2 Spike protein
Researchers have found that the S1/S2 cleavage of the SARS-CoV-2 Spike protein could be a potential target for COVID-19 therapeutics.
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Analysis conducted on glycan structure from sheep prion strains
Using liquid chromatography/mass spectrometry, researchers have revealed no major differences in glycan structures in two prion strains.
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RNA sequencing reveals insight into tuberculosis infection
Using single-cell RNA sequencing, researchers have shown that interferon response is correlated with tuberculosis progression.
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Mutations in SARS-CoV-2 Spike could lead to greater infectivity, study shows
Comparing the original SARS-CoV-2 Spike protein with a mutated version, researchers have potentially revealed why the mutated version is dominant.
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ebook: Vaccines in the digital age
In this ebook, we’ll see how digitally enabling your organisation can increase capacity and improve vaccine production.
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Whitepaper: Automated cell culture and screening
This whitepaper describes the automated culturing of hiPSC-derived cells for high-throughput phenotypic screening, using validated phenotypic assays.
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N439K variant of SARS-CoV-2 is resistant to some neutralising antibodies, shows study
The N439K mutation improves the interaction between SARS-CoV-2 Spike protein and the viral receptor ACE2 and eludes antibody-mediated immunity, say investigators.
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Whitepaper: Why BioPharma Lifecycle Management?
In this whitepaper we explore some of the major bottlenecks in the development lifecycle and the current barriers to effective digital transformation.
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Application note: Automated Simple Westerns in targeted protein degradation
Learn how Simple Western automated immunoassays screen degraders and IMiD compounds to quantify degradation activity, providing accurate DC50 and Dmax values.