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From the world’s flagship neutron science facility, Institut Laue-Langevin (ILL), Matthew Blakeley shares insights into how they are harnessing the power of neutrons to aid their search for new cancer treatments.
Researchers prove it's possible to control a visual behaviour of a mouse by activating neurons in its visual cortex.
A unique method for studying proteins has been developed which could open new doors for medicinal research.
A new medical imaging tracing method has been discovered by scientists which can better track drugs in the body.
Researchers have been able to image noroviruses, providing significant information for the development of therapeutics.
The potential of three-dimensional cell culture models is now well-recognised by scientists; however, there are still some challenges. Margaritha Mysior and Jeremy Simpson address some of the common challenges of working with spheroids and organoid models – including how they are developed and how to obtain high-resolution, high-content images and…
Scientists from LifeArc, an independent medical research charity in the UK, explain how they’re using the latest imaging technologies to progress drug discovery campaigns and identify the most promising candidates for antibody-based therapies.
High-content screening (HCS) approaches have become increasingly common in drug discovery with HCS technologies integrated across the drug discovery pipeline. Here we discuss recent developments in this arena.
Image-based phenotypic profiling of small molecules has been used for identification and characterisation of small molecules in drug discovery and can provide important insights into their mechanisms of action (MOA). This article discusses the use of phenotypic profiling in drug discovery and how machine-learning algorithms could help improve objectivity, processing…
A new method of assessing the actions of medicines by matching them to their unique protein receptors could accelerate drug development.
Integrating hardware, software and fluorescent labels for optimised HCA assay development.