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Issue #4 2020

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Tracking SARS-CoV-2 with genome sequencing

2 December 2020 | By

Researchers have been tracking SARS-CoV-2 by sequencing the genomes of virus samples collected from diagnostic testing. They hope that using next generation sequencing (NGS) on SARS-CoV-2 will help to accurately diagnose the novel coronavirus, identify mutations and track its history. This article explores the findings of their latest study and…

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Biosynthetic polysaccharide-based drugs and nutraceuticals from non-animal sources

2 December 2020 | By ,

Glycosaminoglycans (GAGs) are a class of naturally occurring polysaccharides that play vital roles in cellular functions. GAGs (eg, hyaluronic acid, heparosan, chondroitin, chondroitin sulfate, heparan sulfate and heparin) have also been utilised in biopharmaceutical and nutraceutical industries. Animal-sourced GAGs can contain process impurities and contaminants, which may result in adverse…

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Predicting COVID-19 susceptibility and severity

2 December 2020 | By

Recent reports suggest that both clinical and genetic risk factors may contribute to COVID-19 susceptibility and severity. Catherine Ball, Chief Scientific Officer of Ancestry®, discusses results of the company’s COVID-19 Research Study, designed to explore non-genetic and genetic associations with disease outcomes.

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Precision medicine beyond oncology

2 December 2020 | By ,

The field of oncology has successfully applied precision medicine approaches to diagnosis and treatment. Success has been driven by a growing understanding of the underlying biology of cancer; the emergence of innovative tools and technologies for biomarker identification and detection; and considerable advocacy by patients, physicians and policymakers that has…

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Application note: Get the most out of every slide

1 December 2020 | By

Having the ability to get the maximum amount of data out of every slide is of crucial importance in a range of microscopy applications. Achieving this requires maximising the usable area on the slide, the number of observation modes and the number of fluorescent labels available, as well as optimising…

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Development of a physiologically relevant lung model for understanding SARS-CoV-2 infection

27 November 2020 | By

COVID-19 is known to infect the lungs; however, the dynamics of viral infection and replication are poorly understood. Alongside the Liverpool School of Tropical Medicine, Professor Lyle Armstrong and colleagues have been working to develop a human lung epithelium model of SARS-CoV-2 infection and replication. In this article, he describes…