High throughput screening for deep mining of antibody repertoires, Dr. Stefan Moese, Novartis, Switzerland

Supported by:

13 June 2018


Antibodies are the key drivers of new drug development based on biologics rather than small molecules. Multiple blockbuster drugs have emerged in this area, many more are in the pipeline. In this webinar Stefan Moese talks about the implementation of a high throughput screening approach for mining of antibody repertoires at ESBATech.

Putting the screening activity in the context of the full drug discovery challenge, the theoretical concept is described and then its translation to a real research setting. Different analytical tools, such as flow cytometry of B-cells, immun-binding assays, cell based assays and more are discussed. The data challenge is also part of the webinar, and the automation used to execute the screening tasks in a high-throughput fashion is discussed.

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