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The promise of 3A5C7 mAb in the treatment of morphine tolerance

30 January 2024 | By ,

Morphine is a frequently used analgesic that activates the mu-opioid receptor (MOR), which has prominent side effects of tolerance. A monoclonal antibody (mAb) precisely targeting MOR, named as 3A5C7, was developed to treat morphine tolerance by enhancing morphine-induced MOR endocytosis via GRK2/β-arrestin2 pathway. In this Q&A session with Dr Jia-Jia…

webinar

Developing next generation non-replicative HSV-1 vectors for sustainable and more precise gene therapies

22 January 2024 | By Drug Target Review, sponsored by Bio Rad Technologies

Watch this webinar to learn how the challenges with using certain viral vectors in gene therapy has advanced the development of a new generation of precise vectors with sustainable effects. Our experts outline the limitations of existing vectors and how these can be overcome using modified recombinant non-replicative herpes simplex…