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Drug Discovery Processes
Webinar highlights: Recent advances in diagnostics and treatments – from small molecules to cellular therapies
7 December 2018 | By Bio-Techne
The webinar presented an overview of the pre-clinical milestones, the current status of the global drug pipeline and a description of a number of novel drugs undergoing clinical trials.
Three-dimensional cell cultures (spheroids, organoids) are becoming widely used as a new predictive tool in early drug discovery. The use of 3D cell cultures is believed to provide a more physiologically relevant response than monolayer (2D) cell cultures because they closely mimic the extracellular matrix and cell-cell interactions that occur…
6 December 2018 | By Steven Jarvis (Scientific Director - Global Strategic Accounts at Merck)
The basic premise of drug discovery screening necessitates that the biological assays upon which it depends can be performed in a reproducible manner. In addition, the techniques employed must generate results that are biologically relevant and actionable.
5 December 2018 | By Iqra Farooq (Drug Target Review)
Frizzled receptors, from the GPCR family, could soon be a target to treat numerous diseases such as cancer, fibrosis and CVD...
4 December 2018 | By PerkinElmer
Data integrity and computerised system validations (CSV) have become an area of increased scrutiny for regulatory agencies over the last several years. Understanding how the agencies view data integrity is critical for laboratories to maintain complete compliance.
Expert view: Tackling drug discovery inefficiencies requires diverse libraries, technologies with broader applicability and actionable insights
4 December 2018 | By Stefan Duhr (CEO at NanoTemperTechnologies)
Inefficiencies in drug discovery are hard to ignore when despite ever-increasing investment in pharmaceutical research and development, the number of new drugs approved by the US Food and Drug Administration (FDA) remains low.
Despite being one of the more ancient aspects of immunity, therapeutic modulation of the innate immune system has rarely been attempted. Innate immunity is intrinsically linked to the generation of inflammation – necessary for signalling to the adaptive immune system but often self-perpetuating and over-exaggerated, leading to deleterious effects, including…
Application note: Integrated biologics – Enabling high-throughput drug discovery at Amgen with Thermo Fisher™ Platform for Science™ Software
29 November 2018 | By Thermo Fisher Scientfic
Every day scientists are working to discover and develop new therapies and treatments to change the lives of patients suffering from serious and debilitating illnesses. Amgen Inc. has made it a priority to unlock the potential of biology to discover, develop, manufacture, and deliver innovative therapeutics to patients.
Application note: Direct measurements of cellular metabolism for identification of mitochondrial drug targets
Drug target identification has a key role in the drug discovery value chain. A critical step in the development of pharmaceuticals is identifying the direct targets of potential drug candidates as well as distinguishing any secondary or off-target effects...
29 November 2018 | By Drug Target Review
UCLA-led research has shown how using electron microscopes to analyse small molecules coud be beneficial in speeding up the drug discovery process...