Bacteria compete for ‘ownership’ of human tissue
11 December 2018 | By Drug Target Review
Research has shown how the same species of bacteria compete for space on human tissue, with researchers saying the mechanism could be used in research...
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Drug Discovery Processes
Webinar highlights: Recent advances in diagnostics and treatments – from small molecules to cellular therapies
7 December 2018 | By Bio-Techne
The webinar presented an overview of the pre-clinical milestones, the current status of the global drug pipeline and a description of a number of novel drugs undergoing clinical trials.
Expert view: Three-dimensional cell cultures as predictive tools in early drug discovery
6 December 2018 | By Leena Mol Thuruthippalli (Senior Product Manager – Protein & Cell Analysis at Thermo Fisher Scientific)
Three-dimensional cell cultures (spheroids, organoids) are becoming widely used as a new predictive tool in early drug discovery. The use of 3D cell cultures is believed to provide a more physiologically relevant response than monolayer (2D) cell cultures because they closely mimic the extracellular matrix and cell-cell interactions that occur…
Immunoassay developed to detect small molecules
6 December 2018 | By Drug Target Review
An immunoassay developed to analyse small molecules has shown 50 times greater accuracy than current systems of analytical techniques...
Expert view: Challenges in drug discovery screening
6 December 2018 | By Steven Jarvis (Scientific Director - Global Strategic Accounts at Merck)
The basic premise of drug discovery screening necessitates that the biological assays upon which it depends can be performed in a reproducible manner. In addition, the techniques employed must generate results that are biologically relevant and actionable.
Frizzled receptors could be drug targets for treating major diseases
5 December 2018 | By Iqra Farooq (Drug Target Review)
Frizzled receptors, from the GPCR family, could soon be a target to treat numerous diseases such as cancer, fibrosis and CVD...
Webinar preview: Compliance with data integrity and computerised system validations
4 December 2018 | By PerkinElmer
Data integrity and computerised system validations (CSV) have become an area of increased scrutiny for regulatory agencies over the last several years. Understanding how the agencies view data integrity is critical for laboratories to maintain complete compliance.
Expert view: Tackling drug discovery inefficiencies requires diverse libraries, technologies with broader applicability and actionable insights
4 December 2018 | By Stefan Duhr (CEO at NanoTemperTechnologies)
Inefficiencies in drug discovery are hard to ignore when despite ever-increasing investment in pharmaceutical research and development, the number of new drugs approved by the US Food and Drug Administration (FDA) remains low.
Targeting innate immunity to treat disease: potential therapeutic applications
3 December 2018 | By Christopher Schaber - PhD, Oreola Donini - PhD - Chief Scientific Officer, President - Chief Executive Officer, Richard Straube - MD - Chief Medical Officer
Despite being one of the more ancient aspects of immunity, therapeutic modulation of the innate immune system has rarely been attempted. Innate immunity is intrinsically linked to the generation of inflammation – necessary for signalling to the adaptive immune system but often self-perpetuating and over-exaggerated, leading to deleterious effects, including…
ZFP64 protein is key to deadly blood cancer MLL
3 December 2018 | By Drug Target Review
ZFP64, an inconspicuous MLL fusion protein was found to be neccessary for the production of MLL proteins, and could be targeted to inprove outcomes of MLL...
Application note: Integrated biologics – Enabling high-throughput drug discovery at Amgen with Thermo Fisher™ Platform for Science™ Software
29 November 2018 | By Thermo Fisher Scientfic
Every day scientists are working to discover and develop new therapies and treatments to change the lives of patients suffering from serious and debilitating illnesses. Amgen Inc. has made it a priority to unlock the potential of biology to discover, develop, manufacture, and deliver innovative therapeutics to patients.
Application note: Direct measurements of cellular metabolism for identification of mitochondrial drug targets
29 November 2018 | By Brian P. Dranka, George W. Rogers, Sarah E. Burroughs
Drug target identification has a key role in the drug discovery value chain. A critical step in the development of pharmaceuticals is identifying the direct targets of potential drug candidates as well as distinguishing any secondary or off-target effects...
Technique to identify small molecules could speed up drug discovery
29 November 2018 | By Drug Target Review
UCLA-led research has shown how using electron microscopes to analyse small molecules coud be beneficial in speeding up the drug discovery process...
Freeze-dried vaccine may help eradicate polio
27 November 2018 | By Drug Target Review
Researchers have developed a polio vaccine that doesn't require refrigeration, meaning it could someday be used all over the world...
Transporting proteins into cells to mitochondria
26 November 2018 | By Drug Target Review
J-proteins such as Xdj1, as helpers of the heat shock protein 70 chaperones, and were found to be involved in the transport of proteins to the mitochondria...
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