This issue includes a discussion on the future of high-throughput screening through collaboration, an analysis of mass spectrometry as a structural biology tool and an exploration of the challenges of hit-to-lead when researching tropical diseases. Also in the issue are articles on immuno-oncology and assays.
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High Throughput Screening (HTS)
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Researchers have created a new high-throughput screening system which could identify new drugs by focusing on nucleotide metabolism.
A pioneering team of scientists from Rice University has discovered that a particular combination of chemotherapeutics, including mitocans that target mitochondria, form a powerful treatment for acute myeloid leukaemia patients.
A machine-learning algorithm has been created that automates high-throughput screens of epigenetic medicines.
A world-first compound that can keep cells alive and functioning in a healthy state could be revolutionary for medical emergencies.
A study that identified 12 novel compounds that may prove valuable against new drug targets for leishmaniasis and Chagas disease was not without complication. Here, we discuss the findings but also the challenges the researchers reported in their hit-to-lead study.
Researchers have used a high-throughput screening method to test over 125,000 molecules and identify a new class of antibiotics.
A study using high-throughput screening has revealed some promising compounds that could be used in future cancer treatments.
Application note: Cell line development: accelerating antibody discovery by monitoring titre and glycosylation with the Octet® platform
Cell line development typically includes the screening of thousands of clones to identify the few that are stable, grow as expected and produce high yields of the bioproduct.
A new platform has enabled an unprecedented level of control over individual molecules and particles on a chip for high-throughput analysis.
Molecular Devices, LLC, today announced the launch of the next generation of its FLIPR® Penta High-Throughput Cellular Screening System.
Image-based phenotypic profiling of small molecules has been used for identification and characterisation of small molecules in drug discovery and can provide important insights into their mechanisms of action (MOA). This article discusses the use of phenotypic profiling in drug discovery and how machine-learning algorithms could help improve objectivity, processing…
Automation offers a choice of powerful ways to design and execute high-quality laboratory research. The use of lab automation is now pervasive in biomedical labs, offering versatile platforms on which to perform an ever‑expanding array of tasks free of human errors, and a unique means to address the problems associated…
Current technologies that measure molecular interactions for drug discovery slow down and complicate screening. Dianthus is the answer to the demands for fast, non-stop, highly sensitive hit identification, hit validation and lead optimisation.
18 February 2019 | By Tecan and Ncardia
Ncardia, will discuss the application of human iPSC-derived cell-based assays and high throughput screening for drug discovery and development.