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Microglia critical for neurodegeneration in mice, study finds
Microglia brain immune cells are vital in conjunction with the APOE4 gene during the development of Alzheimer’s in mouse models, researchers have found.
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Victoria Rees (Drug Target Review)
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AI can predict which research will translate to clinical trials
Researchers have created an AI model that analyses the citations of studies, predicting their potential for eventual clinical application.
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Study reveals potential of gamma delta T cells to combat breast cancer
Researchers have discovered that a specific subset of gamma delta T cells can be found in higher numbers of breast cancer survivor tissue, indicating its role in fighting the condition.
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Research reveals calcium signalling pathway in T cells
A study has uncovered the mechanism behind calcium entry and exit into T cells, which could be used in development of autoimmune disease treatments.
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Sir Peter Ratcliffe awarded joint Nobel Prize for Physiology or Medicine
The researcher Sir Peter Ratcliffe and two others have been jointly awarded the Nobel Prize for Physiology or Medicine 2019.
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Researchers use new CRISPR method to alter specific bacteria strains
A study has demonstrated how to use CRISPR to deliver DNA to particular bacteria, which could be used as an alternative to antibiotics.
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Antibodies used to treat and reverse MS symptoms in mice
Researchers have identified a protein on the surface of cells that cause MS and have used antibodies as an effective treatment for the condition in mice.
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The challenges of hit-to-lead in drug discovery
A study that identified 12 novel compounds that may prove valuable against new drug targets for leishmaniasis and Chagas disease was not without complication. Here, we discuss the findings but also the challenges the researchers reported in their hit-to-lead study.
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Protein receptor linked to cell death imaged for the first time
Researchers have imaged an inflammation-related protein receptor on cell membranes which could inform future drug designs to prevent cell death.
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Potential treatment for heart attacks discovered by researchers
Researchers have uncovered a treatment that may be used to treat heart attacks or to prevent heart failure, using the circadian clock.
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NKAP gene mutation linked to rare developmental disease
A study has revealed that a mutation in the NKAP gene causes a rare syndrome, providing researchers with the potential to develop treatments for the condition.
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Researchers discover new pathway to treat Ewing sarcoma
A study has demonstrated that blocking certain receptors in mice reduced Ewing sarcoma growth and metastasis, which could be used within future treatments.
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Protein responsible for muscle degeneration identified
A study has demonstrated that a certain protein is critical in the decline of muscle regeneration, with the researchers also showing how to inhibit this process in mice.
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In vitro toxicology and toxicity testing market to exhibit CAGR of 9.3 percent
The worldwide market for in vitro toxicology and toxicity testing is predicted to be worth $12.7 billion by the end of the forecast period.
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Whole genome sequencing could be used to improve cancer treatments
Researchers have used whole genome sequencing to analyse breast cancers and reveal which are more responsive to treatments, which could improve the development of oncologic therapies.