Researchers say that inhibiting NLRP3 with Dapansutrile could be an effective strategy to prevent melanoma tumour growth.
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Victoria Rees (Drug Target Review)
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Scientists have visualised the spatial and temporal distribution of neural stem cell activation in zebrafish models.
Scientists have shown that culturing cells with a modified serum could allow drugs to be screened for toxicity earlier during research.
Researchers have shown that an mRNA delivery system can be used to produce the BDNF protein in rats to protect neurons from ischemia.
Scientists have developed PF74-like small molecules able to target the HIV-1 capsid protein, identifying four potent compounds.
Using cryo-electron microscopy, researchers have shown that the Spike (S) protein on cells exposed to the AstraZeneca vaccine is highly similar to the SARS-CoV-2 S protein.
Researchers have created a new single-cell transcriptomics approach that cryopreserves cells, limiting the stress they are put under.
Studying the mouse gene Ophn1, researchers have found its removal causes stressed behaviours, also identifying three ways to reverse this effect.
A model of the SARS-CoV-2 Spike protein surface has uncovered vulnerabilities that researchers say could inform the development of COVID-19 vaccines.
Researchers have shown that miR-29 can control brain maturation in mammals, presenting a target for autism, epilepsy and other conditions.
A team has developed a lotus-root-shaped construct to deliver iPSC-derived pancreatic beta-cells to patients with type I diabetes mellitus.
Using a high-brilliance X-ray lightsource and protein crystallography, researchers have identified two drugs that inhibit the main protease of SARS-CoV-2.
The Atlas of Variant Effects Alliance will develop a map of human genetic variants to advance the understanding and treatment of disease.
A new VLP-based Zika virus vaccine is able to protect mice completely from infection, researchers have found.
Researchers have elucidated the 3D structure of the Taspase 1 enzyme, known to be involved in a range of cancers.