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Medical screening is a strategy used to identify the possible presence of an as-yet-undiagnosed disease in individuals without signs or symptoms.
Unique considerations surrounding the bureaucracy and oversight in the use of human biospecimens in the European Union.
High content data derived for complex immuno-oncology research facilitates a deeper understanding of the tissue microenvironment.
A recent study has identified the DBC1 gene which leaves cancer cells more exposed to therapies.
Progressing drug discovery projects to a stage that attracts commercial interest is a challenging endeavour, evidenced by the fact that only a small proportion of drug discovery projects are successfully progressed to such a stage. A major cause of this is the lack of comprehensive profiling of compounds prior to…
Application note: Detection of anti-drug antibody (ADA) using single molecule counting (SMCTM) technology
All biological therapeutics have the potential to induce an immunemediated response ranging from benign to severe adverse effects.
A new study has found a small molecule which prevents cancer cells from mutating and becoming resistant to chemotherapy.
Image-based phenotypic profiling of small molecules has been used for identification and characterisation of small molecules in drug discovery and can provide important insights into their mechanisms of action (MOA). This article discusses the use of phenotypic profiling in drug discovery and how machine-learning algorithms could help improve objectivity, processing…
New research could lead to novel treatments for autoimmune disorders and sheds light on the causes of autoimmunity.
Typically, early drug discovery campaigns start with the screening of chemical libraries to identify candidate chemotypes modulating a particular target and/or phenotype. Success of the primary screening depends on multiple factors related to both biology and chemistry. These include the target’s druggability, sensitivity and specificity of assay system, composition and…
Integrating hardware, software and fluorescent labels for optimised HCA assay development.