Gut microbiome directs immune system to fight cancer
4 April 2019 | By Drug Target Review
The advent of immune checkpoint inhibitors is a major breakthrough in cancer immunotherapy...
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Drug Development
The key to greater efficacy in cancer treatment?
25 March 2019 | By Drug Target Review
Mitochondria are found to be associated with the effectiveness of oncological drug therapies...
Optical imaging technique to detect tiny tumours
8 March 2019 | By Iqra Farooq (Drug Target Review)
A method of imaging using longer wavelengths could mean that tiny tumours and clusters of cancer cells may be detected earlier than current methods allow...
Phenotypic screening using iPSC-based human disease biology
18 February 2019 | By Tecan and Ncardia
Ncardia, will discuss the application of human iPSC-derived cell-based assays and high throughput screening for drug discovery and development.
Developing a blood test for pain measurement
14 February 2019 | By Iqra Farooq (Drug Target Review)
A blood test to measure pain has been developed, and could potentially aid physicians with more accuracy in diagnosis and prescriptions...
Development of a gel for liver cell culture on microchips
13 February 2019 | By Iqra Farooq (Drug Target Review)
Hydrogels could be used to build organs on chips to test potential medications, with the aim that they could potentially replace animal studies...
Hit-to-lead discovery at a nonprofit research institute
7 February 2019 | By Anthony Pinkerton
Small molecule drug discovery has long been the domain of pharmaceutical companies, and that’s not likely to change anytime soon. But there’s a cadre of universities and nonprofit research institutes that have embraced drug development at its earliest stages, in some cases identifying and optimising compounds that target possible disease-driving…
Mavoglurant could improve eye gaze in fragile X patients
25 January 2019 | By Iqra Farooq (Drug Target Review)
A first stage trial involving the experimental drug mavoglurant has shown early success in the treatment of gaze avoidance in fragile X syndrome patients...
Genetic study reveals possible new routes to treating osteoarthritis
23 January 2019 | By Dr Zara Kassam (Drug Target Review)
Scientists discover new genes and biological pathways linked to osteoarthritis, which could help identify starting points for new medicines...
How gut bacteria affect the treatment of Parkinson’s disease
21 January 2019 | By Dr Zara Kassam (Drug Target Review)
Researchers have investigated the ability of gut microbiota to influence the bioavailability of levodopa, a drug used in the treatment of Parkinson's...
Small molecules could have big benefits in the battle against cancers
15 January 2019 | By Douglas J. Swirsky
Immunotherapy and targeted treatments, including targeted chemotherapy, continue to show great potential in cancer care. Future steps in their development will involve improving their ability to treat a wider range of cancers and a broader cross-section of the patient population, especially those for whom current treatments have shown limited efficacy...
Targeting innate immunity to treat disease: potential therapeutic applications
3 December 2018 | By Christopher Schaber - PhD, Oreola Donini - PhD - Chief Scientific Officer, President - Chief Executive Officer, Richard Straube - MD - Chief Medical Officer
Despite being one of the more ancient aspects of immunity, therapeutic modulation of the innate immune system has rarely been attempted. Innate immunity is intrinsically linked to the generation of inflammation – necessary for signalling to the adaptive immune system but often self-perpetuating and over-exaggerated, leading to deleterious effects, including…
Application note: Transforming your bioanalysis operations – is a lack of insight slowing you down?
29 November 2018 | By IDBS
Many bioanalytical labs work with a crowded and siloed set of systems and processes. From part electronic to part paper-based workflows to standalone point-solutions, the result is a lack of insight into data and slower reporting and results handling.
Application note: Direct measurements of cellular metabolism for identification of mitochondrial drug targets
29 November 2018 | By Brian P. Dranka, George W. Rogers, Sarah E. Burroughs
Drug target identification has a key role in the drug discovery value chain. A critical step in the development of pharmaceuticals is identifying the direct targets of potential drug candidates as well as distinguishing any secondary or off-target effects...
Freeze-dried vaccine may help eradicate polio
27 November 2018 | By Drug Target Review
Researchers have developed a polio vaccine that doesn't require refrigeration, meaning it could someday be used all over the world...
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