A study that identified 12 novel compounds that may prove valuable against new drug targets for leishmaniasis and Chagas disease was not without complication. Here, we discuss the findings but also the challenges the researchers reported in their hit-to-lead study.
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An assay is an analytical procedure in laboratory medicine, pharmacology and molecular biology for measuring the activity of a target entity.
Automated fluorescence imaging and quantification of cell viability, with EVOS cell imaging system
High-throughput fluorescence imaging and analysis of spheroids - tips, tricks, and tools to efficiently grow, stain, image, and analyze 3D cell cultures
Vernalis Research is based at Granta Park in Cambridge, UK and specialises in the development and application of fragment- and structure-based drug discovery methods. Nikki Withers met with Vernalis’ Research Director, James Murray, to discuss the company’s innovative approach to target discovery and how they sustain symbiotic collaborations to progress…
There is still much to be done regarding how training is delivered and monitored in core technologies such as flow cytometry. Here, Derek Davies outlines the approaches his team at The Francis Crick Institute are taking to train users of such technologies to ensure quality data is obtained and best…
As technology advances and scientific research progresses at a rapid pace, data is being generated in ever-larger quantities. Even with the forward strides in technology and advances in data processing, a common problem widely acknowledged by the scientific community is that of reproducibility. In this article, Matjaz Hren discusses the…
Application note: Multiplexed automated imaging assay for cardiotoxic compounds using the ImageXpress Pico system
There is an increasing need to expand the variety and complexity of cell-based assays for biologic research and drug discovery.
Application note: Faster and more reliable quantification of oligonucleotide interaction with human serum albumin using MST
Antisense oligonucleotides are an emerging therapeutic option for treating diseases with known genetic origin.
It is predicted that there will be 70 new monoclonal antibody (mAb) biotherapeutics available by 2020.
With the recent rise in the prevalence of celiac disease, monitoring gluten levels in food and beverage has become increasingly important as more people strive to avoid gluten.
Scientists have shown that there are molecules to remodel the gut microbiome and turn an unhealthful gut into a more healthful one for the first time.
There is an increasing need to expand the variety and complexity of cell-based assays for biological research and drug discovery.