Product hub: Scalable and automated 3D cell cultures for high-throughput and high-content screening
Read about hydrogels that provide defined and tuneable material properties that allow the controlled inclusion of biochemical cues.
In drug development, high-throughput screening (HTS) is a commonly used method where the objective is to identify lead compounds with biological activity. Many cell-based HTS and high-content screening (HCS) assays are still carried out using traditional two-dimensional (2D) cultures. However, the highly artificial HTS monolayer 2D cultures are thought to significantly impact the predictive value of compound screens, leading to high failure rates in drug discovery. Advanced, but simple-to-use three-dimensional (3D) cell-based assays for HTS and HCS could work as a solution to provide more physiologically-relevant cell culture models.