Thanks to new developments with induced pluripotent stem cells enabling generation of human neurons, scientists can more precisely analyse the effects that chemicals have on human cells. This article describes research into the effects of cannabis on neuronal development and implications of its legalisation in Canada.
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7 June 2019 | By Victoria Rees (Drug Target Review)
Researchers have grown identical brain organoids for the first time, opening avenues for neurological research.
Beyond ‘simple’ biology – turning organoids, spheroids, and 3D tissue models into physiologically relevant high-content assays for drug discovery
11 December 2018 | By Matthias Nees and Malin Åkerfelt (University of Turku - Finland)
Drug discovery is still hampered by the routine use of cell-based models that often fail to recapitulate the truly relevant biological complexity of the corresponding disease. Just moving from two- (2D) towards three-dimensional (3D) cell culture model systems like spheroids and organoids is not enough to generate truly representative and…
6 December 2018 | By Steven Jarvis (Scientific Director - Global Strategic Accounts at Merck)
The basic premise of drug discovery screening necessitates that the biological assays upon which it depends can be performed in a reproducible manner. In addition, the techniques employed must generate results that are biologically relevant and actionable.
Application note: Production of human induced pluripotent stem cell-derived cortical neurospheres in the DASbox® Mini Bioreactor System
29 November 2018 | By Eppendorf
There is substantial interest in the scientific community in using human induced pluripotent stem cell (hiPSC)-derived neural cells to study basic mechanisms of brain development, neuronal function, and drug-induced effects. In vitro-generated brain organoids are promising models, because they show a remarkable degree of maturation and can be kept in…
26 November 2018 | By Drug Target Review
In this issue: Omics-informed drug target discovery in combating emerging infectious diseases, measuring intracellular ATP levels to access compound-mediated cellular toxicity, and turning organoids into physiologically relevant high-content assays for drug discovery.
2 October 2018 | By Drug Target Review
Researchers have implemented oxygen sensitive nanoparticles into a gel material that can be used for 3D printing of complex, biofilm and tissue-like structures...
13 April 2018 | By Drug Target Review
Single-cell technology and organoids enable researchers to study cancer-specific processes...
12 February 2018 | By Dr Zara Kassam (Drug Target Review)
Researchers have bioengineered organs that are free from the risk of tumour growth--and of sufficient volume and size for viable transplant...
13 December 2017 | By Dr Zara Kassam (Drug Target Review)
An international team of researchers have developed 3D cell cultures in which genes can be specifically modified to improve the use of targeted anti-cancer drugs...
14 September 2017 | By Dr Zara Kassam (Drug Target Review)
Researchers have developed a method, based on CRISPR-Cas9 technology in organoids, to study the genetic cause of hereditary forms of cancer...
8 September 2017 | By Dr Zara Kassam (Drug Target Review)
Engineers have demonstrated a technique for making 3-D-printed biomaterials that can degrade on demand, which can be useful in making intricately patterned microfluidic devices...
26 June 2017 | By Niamh Marriott (Drug Target Review)
Degeneration of cartilage and other joint tissues is a major cause of disability.
15 May 2017 | By Niamh Marriott (Drug Target Review)
'Mini organs' may aid in understanding and treating respiratory diseases.