All Article articles – Page 23
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ArticleCAR-NK cells: promising for cancer therapy
The suitability of NK cells for cancer therapy has been challenged by some investor and business interests because of limited efficacy data, is this a valid belief at the present stage of development of the immune therapy field?
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Natural killer cells: Looking good for cancer therapy
The suitability of NK cells for cancer therapy has been challenged by some investor and business interests because of limited efficacy data, but is this belief at the present stage of development of the immune therapy field?
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ArticleAntimicrobial resistance with Recce Pharmaceuticals
In this exclusive interview, Drug Target Review's Taylor Mixides interviews James Graham, CEO of Recce Pharmaceuticals, they explore the company's approach to combat the growing global threat of antimicrobial resistance (AMR). Recce Pharmaceuticals is at the forefront of developing a new class of synthetic anti-infectives with a unique mechanism of ...
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ArticleBreaking down barriers across the DMTA cycle
In this article, David Bardsley, Commercial Director, and Nick Foster, Vice President of Discovery CRO at Cresset, explore the challenges that occur when approaching drug discovery in silos and how harnessing advances in technology can help to overcome them.
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ArticleBreaking new ground in endometriosis treatment
Endometriosis is a debilitating condition that affects millions of women worldwide, causing chronic pain, infertility, and a host of other distressing symptoms. Current treatments offer limited relief, but they do not address the cause of the disease. Professor Hugo Vankelecom, at the helm of the CurE-me project, is on a ...
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ArticleFoxp3 protein governs regulatory T cell genome structure
Foxp3 alters chromatin architecture of regulatory T cells, meaning Foxp3 could become a target for therapies that modulate immunosuppression.
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ArticleHow a dynein subunit maintains neuronal health
Understanding how a molecular transport system inside neurons works could be used for therapeutic approaches to neurodegenerative disease.
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ArticleNavigating the challenges of cell therapies
Cell therapies hold great potential for treating complex diseases, yet they face significant limitations and challenges. Current cell therapies have difficulty distinguishing between healthy and cancerous cells, often resulting in adverse effects. Vittoria's innovative Senza5 platform, with its unique CD5-targeting approach, aims to enhance the efficacy, safety, and speed of ...
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ArticleUnderstanding intracellular processes improves LYTACs therapy
New pathway involved in cellular protein degradation could develop LYTACs therapy and find new treatments for lysosome shortage disorders.
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ArticleThe power of combinations in blood cancers
Haematology research is a cradle of innovation, with many firsts in therapeutic approaches utilising the latest technology for the treatment of blood cancers. Anas Younes, Senior Vice President, Head of Haematology Oncology Research and Development at AstraZeneca, envisions a future where potential cures are within reach for more blood cancers ...
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ArticleHuman organoid research offers insights into gut cell differentiation
How stem cells become enteroendocrine cells using gut organoids could have positive implications for many gastrointestinal diseases.
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ArticleAlternate origin discovered for brain mosaicism and focal epilepsy
Researchers gain insight into how brain tissue is impacted differently by genetic problems compared to the rest of the body.
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ArticleNew molecular insights on medical cannabis
A study explores some key biological mechanisms that help explain the therapeutic effects of medicinal cannabis on inflammation and other disease states. Here, researchers from the European Molecular Biology Laboratory outline their investigations into the effect of tetrahydrocannabinol (THC) on the enzyme Autotaxin.
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ArticleCancer drug discovery: protein-ligand interactions
Dr Rob van Montfort, a leading researcher at the Centre for Cancer Drug Discovery (CCDD) within The Institute of Cancer Research, London, is at the forefront of cancer drug discovery. Focusing on protein-ligand interactions, his work utilises structural biology and biochemical methods to help the discovery of novel small-molecule drugs ...
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ArticleWomen in Stem with Ashley Hall
"Throughout my education I was discouraged by many around me." - This October edition of our Women in Stem series spotlights Ashley Hall, Chief Development Officer of Reneo Pharmaceuticals. Ashley shares her experiences, challenges, and insights. Her STEM journey began with a fascination for science, leading her to overcome initial ...
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ArticleAI in gene delivery vector discovery and design
Dr Fernando Garces, Director of Biotechnology and Innovation at BioMap, discusses the huge potential of AI to deliver successful cell and gene therapy products by optimised design of viral vectors.
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ArticleProtein offers promise for treatment of reproductive conditions
Scientists found that CXCR4 protein expression outside of the uterus is important for pregnancy maintenance.
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ArticleEpisode 24 - Genetic engineering for allogeneic immunotherapy
Listen to this podcast where we dive into genetic engineering, its role and relationship with allogeneic immunotherapy.
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ArticleMicrobiotica: transforming medicine with microbiome magic
In this interview, Anne Neville, Director at Microbiotica, elaborates on the significance of the Microbiotica Culture Collection (MCC) and Microbiotica Reference Genome Database (MRGD), which are fundamental to the development of live biotherapeutic medicines.
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ArticleEmotional scars: stigma with female adult acne
New research presented at the European Academy of Dermatology and Venereology (EADV) Congress 2023 in Berlin, Germany, has highlighted a previously underestimated aspect of acne's impact on individuals: its profound influence on social perception.