All Drug Development articles – Page 27
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ArticleRevolutionary nanoparticles enable gene-editing in lungs
This article outlines the development of a new type of nanoparticle that can perform gene-editing in the lungs. Scientists from MIT and the University of Massachusetts Medical School have collaborated to create this Ribonucleic acid (RNA) delivery particles, which have the potential to revolutionise the treatment of lung diseases such ...
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NewsCombination therapy prevails against BET inhibitor resistance
St. Jude Children's Research Hospital, US, scientists created a new combination therapy method to tackle drug resistance in a type of leukaemia with KMT2A gene rearrangement.
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Article2023 drug discovery forecast: emerging trends and disruptors revolutionising the industry
With advancements in artificial intelligence, precision medicine and gene editing, the field of drug discovery is undergoing a rapid transformation. In this article, Drug Target Review’s Izzy Wood gets the insider knowledge from industry leaders at SLAS 2023, who are experiencing these changes first hand.
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NewsNew drug provides optimism for individuals suffering from heart failure
A newly developed drug displays potential in treating both heart failure and the related sleep apnea.
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NewsNew shape-shifting antibiotics could solve drug-resistant bacteria
US scientists have developed antibiotics that can “shape-shift”, which prevent bacteria from coming resistant against them.
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NewsNovel study suggests alternatives to aspirin with fewer side effects
The new findings could pave the way to safer aspirin alternatives and might also have implications for improving cancer immunotherapies.
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News‘Chemical cube’ tools for building new drugs
In an ongoing discovery programme, a chemical-creation platform is being revealed – based on cubic molecules – that could help breathe new life into tired drugs.
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ArticleDrug Target Review - Issue 1 2023
A new Drug Target Review is now ready to download! This issue features articles which explore antibodies, vaccines and assays.
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NewsNew drug promotes weight loss in mice
US researchers discover compound that limits weight gain in mice with a high-sugar diet, by lowering the mitochondrial magnesium.
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NewsImproving immunotherapy against brain cancer
US scientists suggest that anti-angiogenesis drugs could improve the function and delivery of CAR-T cell therapy.
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NewsWeaponising SARS-CoV-2 spike protein against itself to prevent infection
By creating a drug that is based on part of the SARS-CoV-2 spike protein, US and Finnish researchers can block the virus from entering cells.
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ArticleLatest in lab automation
In this article Drug Target Review's Izzy Wood highlights three of the latest findings using lab automation techniques and technologies that aid scientists.
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ArticleOvarian cancer breakthrough: the potential of rhenium tricarbonyl (TRIP) as a promising anti-tumour drug
In this exclusive article, Drug Target Review’s Izzy Wood highlights ground-breaking ovarian cancer research, after speaking with Dr Benjamin Neuditschko, from the Institute Krems Bioanalytics at IMC Krems.
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NewsCan ketamine act as an antidepressant?
Chronic pain often leads to depression, which US researchers have potentially solved using a mechanism involved with ketamine.
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NewsHost-cell factors involved in COVID-19 infections may predict improved treatments
Researchers have found a potential therapeutic target less vulnerable to potential drug resistance and emerging COVID-19 variants of concern.
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ArticleAllogeneic CAR T-cell therapy: the future of cancer care
In this Q&A, Dr Devon Shedlock discusses Poseida Therapeutics' cancer treatment pipeline and the advances it has made towards developing chimeric antigen receptor (CAR) T-cell therapies for liquid and solid tumours.
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ArticleTransformational vaccines that address global health challenges
Drug Target Review’s Izzy Wood spoke to Joseph Hernandez, CEO of Blue Water Vaccines, about developing transformational vaccines to address significant health challenges globally.
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NewsScientists identify therapeutic targets to overcome radioresistance of brain cancer cells
A new drug could replace the current standard for treating radioresistance brain cancer by sensitising the cancer cells to radiotherapy.
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NewsNew system for safer CRISPR-based gene drive testing and development
US researchers outline the development of a new system for testing and developing CRISPR-based gene drives in the laboratory, and safely converting them into tools for potential real-world applications.
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NewsSARS-CoV-2 antibodies can bind to two viral targets at once
US researchers find that SARS-CoV-2 bivalent antibodies can continue to neutralise Omicron and Omicron lineages.