All articles by Ellen Capon (Drug Target Review) – Page 3
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ArticleThe promise of 3A5C7 mAb in the treatment of morphine tolerance
Morphine is a frequently used analgesic that activates the mu-opioid receptor (MOR), which has prominent side effects of tolerance. A monoclonal antibody (mAb) precisely targeting MOR, named as 3A5C7, was developed to treat morphine tolerance by enhancing morphine-induced MOR endocytosis via GRK2/β-arrestin2 pathway. In this Q&A session with Dr Jia-Jia ...
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ArticleSARS-CoV-2: advancing the production of the ACE2 protein
Producing functional human ACE2 protein in mouse cells provides a new way to study the receptor used by the SARS-CoV-2 spike protein.
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ArticleTherapeutic peptide developed for triple-negative breast cancer
Scientists demonstrate how disrupting the Cx26 molecular complex in triple-negative breast cancer cells slowed tumour growth.
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ArticleRNA interference and its role in Alzheimer’s disease
New data provides an explanation for why, in almost all neurodegenerative diseases, disease sets in as cells age.
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ArticleMechanisms underlying pioneer TF-mediated gene repression
Researchers have made surprising and important findings that may influence organoid and cell reprogramming studies.
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ArticleUsing proteomics to overcome glioblastoma resistance
Using an AI algorithm to predict glioblastoma’s most active kinase, researchers hope for a next-generation precision therapy targeting resistant cancers.
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ArticleDeveloping in-vivo chimeric lungs with pluripotent stem cells
Reverse-blastocyst complementation elucidates the conditions required to form lungs in rat-mouse chimeric models.
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ArticleHow AI is accelerating the future of precision medicine
Dr Ketan Patel, Clarivate, shares his insights about the use of Real-World Data and genomic biomarker data and discusses how researchers can use these to better detect and diagnose diseases.
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ArticleGrowth hormone’s influence on neuropsychiatric disorders
The discovery of a mechanism involving anxiolytic effects of GH may lead to the development of new classes of anxiolytic drugs.
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ArticleBiological robots: a new therapeutic tool
Anthrobots derived from human tracheal cells could perform therapeutic work without initiating an immune response.
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ArticleAllosteric control sites in KRAS protein found
The first complete control map for any protein has been made for KRAS, and four potential drug targets have been discovered.
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ArticleThe promise of nanobodies to neutralise the human norovirus
A new discovery about the dynamic structure of norovirus particles has implications for vaccine development.
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ArticleNew biomarkers found for diabetic kidney disease
Biomarkers found through urinary and exosome proteome profiling have potential for diagnosis and disease monitoring.
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ArticleThe first multi-chamber heart organoids developed
The first multi-chamber cardioids derived from hiPSCs have enabled scientists to investigate heart development and defects.
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AI system develops features of complex brains
An AI system could be used to observe how physical constraints shape brains and impact people with cognitive difficulties.
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ArticleNew understanding of the TMEJ pathway in cancer
Cancer treatment may be majorly impacted by new findings about the polymerase theta-mediated end joining time DNA repair pathway.
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ArticleThe first major set of genetic associations found in long COVID
PrecisionLife’s Dr Sayoni Das, a computational biologist who leads the research and development of bioinformatics pipelines that generate biological insights from PrecisionLife’s core technology and support drug discovery programmes, details a new study. Using combinatorial analysis, genetic variants associated with long COVID have been identified and, furthermore, it has been ...
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ArticleNew gene found plays essential role in stem cell differentiation
Intestinal organoids allowed researchers to understand how Rnf43 and Daam1 influence the balance of stem cell renewal and differentiation.
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Phages could help to tackle antimicrobial resistance
Researchers have found what triggers bacteria to start the CBASS immune response to counter infections by phages.
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ArticleNew technology optimises mesenchymal stem cell extraction
A continuous sorting technique of stem cells on a DLD microfluidic platform may greatly advance cell therapy.
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