News – Page 49
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NewsNew potential drug target is discovered for diabetes treatment
Researchers found heightened SCAN enzyme activity in humans and mice with diabetes results in excessive nitric oxide on insulin receptors.
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Investigating the genetic changes of the DDX3X gene
Using saturation genome editing, researchers have created a map of disease-causing mutations for neurodevelopmental disorders and cancer.
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NewsGene therapy reduces hepatocellular carcinoma in mice
Increasing microRNA-22 overexpression in a gene therapy approach treated HCC in mice, offering promise for its prevention and treatment.
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NewsMutated DECTIN-1 and its implications for autoimmune disease
A discovery about the mutated protein DECTIN-1, that limits the production of T regulatory cells, could lead to more effective drugs.
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Pathogens exert physical force to avoid ingestion within phagocytes
A previously unknown process by which pathogens breach immune defences offers promise for treating infectious diseases.
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NewsAn altered protein can combat the growth of leukaemia cells
Discovery about the NPM1c variant could lead to new drugs targeting the cell growth of acute myeloid leukaemia.
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NewsPotential biomarker found for inflammatory bowel disease
A new approach called reverse metabolomics has discovered molecules that may serve as a biomarker or a therapeutic target for IBD.
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The IKAROS protein is crucial for B cell development
By mapping the genome, scientists have discovered how IKAROS enables differentiation of hematopoietic stem cells into B cells.
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NewsTumour metastasis is blocked by nanodiamonds
Carboxylic nanodiamonds could be a therapeutic agent for cancer, as melanoma cells treated with them showed little to no metastasis.
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Understanding the genetic origins of disease variation
Researchers, using high-resolution mapping and mathematical modelling, have found mechanisms controlling mutation-driven diseases.
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NewsNewly discovered mechanism behind microhaemorrhages
Findings about how erythrocytes interact with brain capillaries offers new potential treatments for brain microhaemorrhages.
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NewsNovel computational model to study cancer dynamics
An advanced computational model enables scientists to study how cancer cells navigate through blood vessels.
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Discovery of molecular pathway could target lung cancer
New findings about how RBM10 inhibits lung cancer growth offers potential for an anti-cancer drug and more personalised treatment.
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NewsPancreatic cancer initiates an immune system response
Studying pancreatic ductal adenocarcinoma tumours, researchers discovered 25 antibodies that responded to antigens.
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NewsNew method to develop therapeutics for autoimmune diseases
A technique that can sort millions of CRISPR-edited cells based on their secretion patterns has been developed to treat autoimmune diseases.
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NewsPotential therapeutic target for ventricular fibrillation found
A signalling mechanism for ventricular fibrillation involving the stress kinases p38γ and p38δ has been discovered.
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NewsNeuropsychiatric symptoms due to excessive brain inflammation
In Alzheimer’s disease patients, irritability and anxiety is likely caused by neuroinflammation, which indicates new therapeutic pathways.
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NewsNew AI model can evaluate invasive breast cancer outcomes
Combining cancerous and non-cancerous cell patterns, the AI model evaluates breast cancer outcomes better than expert pathologists.
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New contamination-detection test to improve T-cell therapy
Method to improve sterility assurance in biopharmaceutic manufacturing will lead to better patient outcomes.
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NewsMitochondria-targeting antibiotics reduce aging in C. elegans
Treating C. elegans with inhibitors of small or large mitochondrial ribosomes extended their median lifespan.