All Digestive disorders articles – Page 4
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ArticleUnlocking the power of stem cell therapy
In this Q&A, founder of Scheer Medical Wellness Dr Alexander Scheer shares his insights, discussing the current challenges in stem cell therapy and how these can be addressed, the advancements in delivery techniques, and stem cells’ overall potential in regenerative medicine.
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A new machine learning tool identifies drugs to minimise fibrosis
The computer model enables a better understanding of how drugs affect fibroblasts and finds a promising candidate to prevent heart scarring.
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ArticleHow 3D human tissue models are transforming drug discovery
In this Q&A, Keith Murphy, CEO of Organovo, discusses how the shift from animal models to 3D human tissues can transform the preclinical space. Among his many insights, he details the limitations of animal models, how Organovo’s 3D human tissue models facilitate a deeper understanding of genetic expression within specific ...
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NewsAdvancing the development of CTLA-4 inhibitors
A new study could result in CTLA-4 inhibitors that promote antitumour responses without causing intestinal diseases, such as colitis.
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NewsPotential biomarker found for inflammatory bowel disease
A new approach called reverse metabolomics has discovered molecules that may serve as a biomarker or a therapeutic target for IBD.
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NewsNew method to develop therapeutics for autoimmune diseases
A technique that can sort millions of CRISPR-edited cells based on their secretion patterns has been developed to treat autoimmune diseases.
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ArticleExploring liver disease therapies
Ochre Bio is at the forefront of therapeutic innovation, focusing primarily on liver diseases. Their core mission revolves around the development of RNA therapies, primarily in the preclinical stage, using a 'human-first' approach. They employ real human tissue, such as 'liver slices' and whole human livers, in their preclinical pipeline ...
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NewsNew colon organoids better resemble both healthy and diseased colons
Researchers have developed organoids with naturally occurring early-stage immune cells, which could lead to effective personalised treatment.
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Potential new targets for chronic liver disease
Fatty liver disease treatments may become more effective after identification and greater understanding of more drug targets.
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NewsProtective mutation found in kidney disease gene
A new discovery about a different protective genetic mutation in apolipoprotein L1 could have major implications for kidney health.
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NewsAlcohol-associated liver disease linked to abnormal splicing deregulation
Splicing deregulation is potential drug target and diagnostic tool, but can be affected by alcohol consumption and thus chronic liver disease.
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NewsExtracellular vesicles could slow spread of fibrosis
US researchers studied the extracellular vesicles of fibrosis and find potential avenue for new treatments and therapeutics.
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NewsHow do cells control the secretion of mucin and insulin?
Spanish researchers looking at two crucial proteins uncover how cells release mucin and insulin, leading to new methods to reset deregulation.
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NewsNew treatment options for chronic kidney disease
Fresh insights from University of Edinburgh into a protein that causes damage in kidneys and hearts could open up new treatment options for chronic kidney disease.
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NewsNew algorithm can predict diabetic kidney disease
Researchers from US and Hong Kong have found that a simple blood sample may help doctors catch kidney disease earlier in type 2 diabetes patients
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ArticleAlgae: a source for prebiotics and drugs to treat IBD
An increasing number of people worldwide suffer from inflammatory bowel disease (IBD). However, no treatment is effective for all patients. In this article, researchers working on the Algae4IBD project explain how algae may represent a valuable source of prebiotics and new therapeutic agents for IBD and other diseases.
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ArticleRevolutionary nanoparticles enable gene-editing in lungs
This article outlines the development of a new type of nanoparticle that can perform gene-editing in the lungs. Scientists from MIT and the University of Massachusetts Medical School have collaborated to create this Ribonucleic acid (RNA) delivery particles, which have the potential to revolutionise the treatment of lung diseases such ...
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NewsInflammation 'brake' gene may impact kidney disease outcomes
Australian researchers uncover a gene that controls inflammation in kidney disease, which could pave the way for more precise disease diagnostics and personalised treatments.
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NewsStudy identifies microbe-gut signalling as potential new treatment for IBD
New research from Cincinnati Children’s Hospital Medical Center suggests blocking IL-22 and IL-1R could offer a promising IBD treatment.
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NewsNew drug promotes weight loss in mice
US researchers discover compound that limits weight gain in mice with a high-sugar diet, by lowering the mitochondrial magnesium.