All Proteogenomics articles
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NewsNew molecular pathway links liver congestion to fibrosis
Japanese researchers have identified a molecular pathway linking chronic liver congestion to fibrosis and tumour formation, offering a potential new target for therapies to prevent serious liver disease.
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ProRNA3D-single: new AI for drug discovery and disease research
Virginia Tech computer scientists have created a new AI tool, ProRNA3D-single, that can generate 3D models of how viral RNA binds to human proteins – a development that could speed up drug discovery.
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NewsProteogenomics: finding targets for never-smoker lung cancer
Through multi-omics analysis, researchers find that oestrogen signalling could be a target for never-smoker lung cancer cases.
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NewsProteogenomic signatures: metastatic prostate cancer risk
Mutation signatures and recurrent copy number alterations correlated with a higher risk for disease progression.
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NewsReducing drug resistance in acute myeloid leukaemia patients
Researchers conducted a proteogenomic characterisation and found that drug exposure changes drug sensitivity.
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NewsA structural insight into HIV drug-resistance mechanisms
New Salk Institute, US, research could lead to the development of new HIV therapeutics that overcome resistance to existing drugs.
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NewsNew insights into influenza A's infiltration of host cells
US researchers have made a significant breakthrough in understanding how the influenza A virus takes over host cells while minimising damage to itself. By studying the protein PA-X, they found that the virus uses a surgical strike approach, selectively degrading host cell RNA while preserving its own replication, shedding light ...
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ArticleThe genetic modifier approach: identifying the right target for rare diseases
In this article, Dr Vincent Blomen, Senior Director of Target Discovery at Scenic Biotech, takes us through the realm of rare diseases. In the case of most of these diseases, a singular genetic anomaly often reigns supreme, yet its impact on patients can be vastly divergent. Enter modifier genes, the ...
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NewsTargeted therapy for treatment-resistant breast cancer
US researchers have uncovered a potential target for treating breast cancer that is resistant to endocrine therapies because of a specific gene mutation.
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ArticleUnderstanding molecular mechanisms behind breast cancer
Oestrogen receptors play a crucial role in breast cancer. By making them therapeutic targets, oestrogen can be regulated with the aim to prevent breast cancer.
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NewsWhat do cancer cells crave?
US researchers uncover the amino acid: arginine, that prompts genetic mutations in cancer cells.