Join this virtual panel to explore how combining pooled CRISPR screening with intracellular protein detection can reveal cellular responses and signalling dynamics that transcriptomics alone may miss.
Single-cell transcriptomics can show which genes are active, but it does not always capture the downstream signalling events that influence how cells behave. For researchers working in target discovery and functional genomics, combining genomic perturbation with protein-level measurements can provide a more complete picture of cellular responses.
In this virtual panel, Dr Lukas Badertscher, VP R&D at Myllia, and Dr Majd Ariss, Principal Scientist at Cell Signaling Technology, explore how pooled CRISPR screening can be combined with InTraSeq Single Cell Analysis to measure RNA, intracellular proteins and surface proteins at single-cell resolution.
The speakers will show how linking genetic perturbations with changes in signalling pathways can reveal biological responses that may be missed by transcriptomic measurements alone. They will also discuss how CRISPR gene knockdown can be used to assess antibody specificity in multimodal assays, supporting greater confidence in protein measurements and their interpretation.
Attendees will gain a clearer understanding of what these approaches can offer target discovery and functional genomics, with the opportunity to put their questions directly to the speakers during a live Q&A.
What will you learn?
- Examine how single-cell CRISPR and protein readouts offer a new perspective on single-cell analysis
- Understand how single-cell genomic perturbations and protein quantification can reveal affected signalling pathways at single-cell resolution
- Assess the efficiency of Myllia’s single-cell CRISPR gene knockdown
- Evaluate antibody specificity in single-cell proteomic tools
Meet the speakers
Dr Lukas Badertscher | Vice President of R&D, Myllia
Dr Lukas Badertscher is Vice President of R&D at Myllia Biotechnology, where he leads high-content CRISPR screening projects in primary human cells to drive unbiased drug target discovery and generate high-dimensional datasets for AI foundation models in biology. Dr Badertscher has more than a decade of experience in functional genomics and CRISPR technologies, having conducted research in both academia and industry at the Friedrich Miescher Institute, ETH Zurich and AstraZeneca.
Dr Majd Ariss | Principal Scientist, Cell Signaling Technology
Dr Majd Ariss is a Principal Scientist at Cell Signaling Technology and a leading expert in single-cell research. He developed InTraSeq Single Cell Analysis, a method for simultaneously measuring RNA and proteins in individual cells, including post-translational modifications.
Dr Ariss has authored and co-authored numerous research publications, including three first-author publications on the application of single-cell technologies. He received his BS and MS in Biochemistry and Molecular Biology from the American University of Beirut and Georgetown University respectively and his PhD from the University of Illinois Chicago, where he was among the first researchers in the state to use high-throughput single-cell RNA sequencing (scRNA-seq) technology and spearheaded the adoption of the Drop-Seq scRNA-seq platform.
After earning his doctorate, Majd was a postdoctoral fellow at the Laboratory of Norbert Perrimon at Harvard Medical School, serving as the single-cell expert. He joined Cell Signaling Technology in 2021
Register now through your Drug Target Review membership.
Is the panel discussion free?
Yes – there is no charge to watch the panel discussion, either live or on-demand.
When will the panel discussion take place?
The webinar will be taking place on 4th November 2026
Can I watch it later?
The panel discussion will become available to watch on-demand shortly after the live webinar takes place.
What are the benefits of attending live?
You’ll be able to ask the speakers your questions, which will be answered live in the Q&A towards the end of the session.
How long will the panel discussion be?
This panel discussion will last up to an hour.
What do I need to watch this panel discussion?
All you need is a computer with an internet connection. We recommend using headphones if possible if you’re in an office environment.
Cracking cell dynamics with single-cell proteomics and CRISPR
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