All articles by Drug Target Review – Page 50
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NewsPotential therapeutic target found for the Zika virus
A discovery about Zika’s enzyme, NS2B-NS3, offers promise for therapeutic targets for Zika and other flaviviruses.
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NewsPotential small molecule drug could treat multiple sclerosis
The new small molecule targets the glutamate system, reducing MS-like symptoms and repairing damaged myelin in two different animal models.
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NewsAstrocytes gain neural stem cell properties after brain injury
Astrocyte plasticity is correlated with upregulation of the Galectin 3 protein, which may greatly contribute to biomarker discovery.
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NewsNew potential drug target is discovered for diabetes treatment
Researchers found heightened SCAN enzyme activity in humans and mice with diabetes results in excessive nitric oxide on insulin receptors.
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Investigating the genetic changes of the DDX3X gene
Using saturation genome editing, researchers have created a map of disease-causing mutations for neurodevelopmental disorders and cancer.
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NewsGene therapy reduces hepatocellular carcinoma in mice
Increasing microRNA-22 overexpression in a gene therapy approach treated HCC in mice, offering promise for its prevention and treatment.
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NewsMutated DECTIN-1 and its implications for autoimmune disease
A discovery about the mutated protein DECTIN-1, that limits the production of T regulatory cells, could lead to more effective drugs.
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Pathogens exert physical force to avoid ingestion within phagocytes
A previously unknown process by which pathogens breach immune defences offers promise for treating infectious diseases.
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NewsAn altered protein can combat the growth of leukaemia cells
Discovery about the NPM1c variant could lead to new drugs targeting the cell growth of acute myeloid leukaemia.
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ReportBeyond the lab: RNA
Download this exclusive content focusing on new RNA editing technology, the challenges and opportunities presented and the potential of RNA-based therapeutics.
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ReportBeyond the lab: screening
Register to access the very latest research, insights and innovations including CRISPR activation screening, AI-aided screening and using nanofibrillar cellulose hydrogels.
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ReportBeyond the lab: cancer research
Our inaugural report is an exploration of the remarkable advancements in cancer research and the field of drug discovery.
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NewsPotential biomarker found for inflammatory bowel disease
A new approach called reverse metabolomics has discovered molecules that may serve as a biomarker or a therapeutic target for IBD.
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The IKAROS protein is crucial for B cell development
By mapping the genome, scientists have discovered how IKAROS enables differentiation of hematopoietic stem cells into B cells.
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NewsTumour metastasis is blocked by nanodiamonds
Carboxylic nanodiamonds could be a therapeutic agent for cancer, as melanoma cells treated with them showed little to no metastasis.
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Understanding the genetic origins of disease variation
Researchers, using high-resolution mapping and mathematical modelling, have found mechanisms controlling mutation-driven diseases.
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NewsNewly discovered mechanism behind microhaemorrhages
Findings about how erythrocytes interact with brain capillaries offers new potential treatments for brain microhaemorrhages.
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NewsNovel computational model to study cancer dynamics
An advanced computational model enables scientists to study how cancer cells navigate through blood vessels.
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Discovery of molecular pathway could target lung cancer
New findings about how RBM10 inhibits lung cancer growth offers potential for an anti-cancer drug and more personalised treatment.
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NewsPancreatic cancer initiates an immune system response
Studying pancreatic ductal adenocarcinoma tumours, researchers discovered 25 antibodies that responded to antigens.