All articles by Drug Target Review – Page 53
-
NewsNew understanding of early breast cancer development
Mammary organoid cultures show the effects of BRCA2 mutations on breast tissue cells, increasing the likelihood of early, targeted treatment.
-
NewsiPSC-derived cells can augment remuscularisation of the heart
Researchers have improved the method of regenerating heart muscle after a heart attack using a combination of iPSC-derived cells.
-
News
Metabolic change in hippocampus indicates Alzheimer's disease
Using RNA sequencing, scientists find that metabolic increase in the brain is an early indicator of Alzheimer's disease.
-
NewsDirect link between hyperinsulinemia and pancreatic cancer found
Excessive insulin levels in people with obesity and type 2 diabetes overstimulates pancreatic cells, initiating disease.
-
NewsSynthetic proteins key to modular nanoparticle design
Researchers have been able to customise nanoparticles to target biological entities, like tumours and viruses.
-
NewsMechanism that triggers dendritic elongation discovered
Short-chain fatty acids produced by intestinal bacteria initiate dendritic elongation, a mechanism that could be used as a drug target.
-
NewsProtein found to control breast cancer metastasis
Scientists have discovered the motor protein dynein commands movement of cancer cells in soft tissue models, offering new clinical targets.
-
NewsNew biomarker advances cancer treatments
Researchers have discovered ways to enhance NIR-PIT to ensure tumours are treated sufficiently and improve patient outcomes.
-
NewsMachine could make CAR T-cell therapy more accessible
Researchers have developed a new bioreactor that can manufacture T cells faster than other technologies, which may advance immunotherapy.
-
NewsRole of enzyme in tumour immune microenvironment identified
Researchers have found that reducing glycosylation on the T cell surface may offer new approaches to cancer immunotherapy.
-
NewsNew molecule disrupts pathways that promote cancer growth
Researchers have discovered a molecule that binds to a cancer cell protein, stopping growth of breast and ovarian tumours.
-
NewsNew small molecule blocks immune response signalling pathway
A new small molecule has great promise for the treatment of autoimmune diseases by inhibiting the proinflammatory signalling pathway.
-
NewsPulmonary ionocytes: unexpected discovery has implications for CF
Researchers found surprising function of pulmonary ionocytes which may affect how cystic fibrosis drugs work.
-
NewsKey epitope can trigger tumour cell death
An epitope on CD95 receptor causes tumour cells to self-destruct and may prolong benefits of CAR T-cell therapy for solid tumours.
-
ArticleEpisode 24 - Genetic engineering for allogeneic immunotherapy
Listen to this podcast where we dive into genetic engineering, its role and relationship with allogeneic immunotherapy.
-
NewsMicrocapsule-loading exosomes to treat vitreoretinal diseases
Scientists have developed ExoCaps, self-healing microcapsules that are more feasible than other cell-based technologies.
-
NewsIntratumoural bacteria drives radiation therapy resistance
Lactate producing bacteria is responsible for rewiring metabolic signalling pathways, causing resistance to radiation therapy.
-
NewsmRNA reverses the glioblastoma immunosuppressive environment
Extracellular vesicles loaded with mRNA encoding interferon-gamma offers promise for treating difficult tumours.
-
NewsNew 3D tumour models simulate complex tumours
3D tumour models enable scientists to offer better treatments and improve survival outcomes for complex conditions like breast cancer.
-
NewsCancer-killing T cells enhanced by engineered bacteria
Bacteria programmed to paint targets on solid tumours for T cells to see eliminates the need for specific antigens.