Professor Paul O’Reilly
Professor Paul O’Reilly is a Professor in Statistical Genetics at the Icahn School of Medicine, Mount Sinai, New York. With a background in mathematics, genetic epidemiology and population genetics, he develops methods and software tools to identify genetic variants leading to disease, to predict complex traits and diseases from genetics, and to investigate the evolution of the genome.
In recent years his lab has focused on polygenic risk scores (PRS), including pathway-based PRS and multi-ancestry PRS, developing tools including PRSice, PRSet and BridgePRS.
Contact info
- Website:
- https://icahn.mssm.edu/
ArticleHow rare genetic variants could uncover new drug targets
What if extreme levels of common traits have a different genetic basis? New research suggests rare, large-effect variants could help explain the extremes and identify potential drug targets.