All articles by Izzy Wood (Drug Target Review) – Page 2
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News'Lava lamp' vesicles show how cells could self-organise
Looking at how cells can self-organise could help us understand the way cells manage biochemical processes.
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NewsHepatic hydrogen sulphide levels are reduced in mouse model of HGPS
HGPS mouse models were used to test the hypothesis that the accelerated aging typical of progeroid mice is associated with reduced hepatic H2S production.
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Rare cause of hereditary cancer missed in younger patients
US investigators find that some cases of Lynch syndrome, the most common hereditary cancer condition, are missed in younger patients under current screening guidelines.
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NewsSubstance abuse inhibits cognitive flexibility
New US research underlines the relationship between substance use and significant modifications to an inhibitory brain circuit, resulting in decreased cognitive flexibility
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ArticleCondensate biology: advancing drug discovery for complex diseases
In this interview with Drug Target Review’s Izzy Wood and Dr Isaac Klein, Chief Scientific Officer at Dewpoint Therapeutics, discuss the innovative potential of condensate biology in revolutionising drug discovery. By targeting disease-driving condensates, Dewpoint’s research pushes boundaries by offering new hope for tackling diseases like ALS and colorectal ...
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NewsScientists discover extensive array of protein folds unexplored in nature
A study out of Japan reveals diversity of protein structures and how they fold in nature, uncovering a myriad of protein topologies.
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NewsGut bacteria linked to fatty deposits in heart arteries
Swedish study reveals a significant link between specific gut bacteria and the development of coronary atherosclerotic plaques, a leading cause of heart attacks.
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ArticleUnleashing the power of AI in target discovery and resilience against disease
In this interview Drug Target Review’s Izzy Wood and Olivia Cavlan, Chief Corporate Development and Strategy Officer at Alchemab Therapeutics Ltd, uncover the untapped potential of AI in target discovery. Alchemab’s revolutionary platform aims to identify common antibodies in resilient individuals and uncover the antigens that contribute to their disease-fighting ...
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NewsBlood plasma proteins hold answers to better understanding long COVID
10 to 20 percent of individuals that get COVID-19 will be later diagnosed with long COVID. New research looks at blood plasma protein patterns that can improve patient outcomes.
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News$3M grant allows milestone in regenerative medicine using blood vessels
US researchers combine revascularisation techniques to allow new blood vessels to rapidly form in an architecturally organised manner.
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NewsUnidentified proteins provide new way to diagnose ovarian cancer
Japanese study has identified three previously unknown membrane proteins in ovarian cancer, using a new detection method consisting of nanotechnology and imaging techniques.
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NewsUS grant supports merging of maths and AI to push frontiers of science
Cornell University launches $11.3 Million Scientific Artificial Intelligence Centre to unlock the potential of human-AI collaboration in scientific discoveries.
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NewsResearchers develop tool that could improve liquid biopsy
A US study has overcome a major obstacle in cell-free DNA (cfDNA) testing or liquid biopsy, offering promising advancements in disease diagnosis and monitoring.
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NewsNew biomarker identified for major depressive disorder
Local gyrification index, which measures cortical folding in the brain, could be a novel neuroimaging marker for major depressive disorder.
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ArticleTargeted protein degradation: turning undruggable targets into druggable targets
Targeted protein degradation (TPD) is a cutting-edge approach in drug discovery that offers a more precise and efficient way to alter cellular pathways, offering the capability to convert 'undruggable targets' into 'druggable targets.' In this article, Drug Target Review’s Izzy Wood interviewed Astellas’ Masahiko Hayakawa, Head of Targeted Protein Degradation, ...
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NewsHow does the brain process and store words we hear?
US researchers studying the brain’s auditory lexicon find implications for stroke survivors and others with brain disorders.
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NewsPure capped mRNA vaccine encourages more effective vaccine development
Japanese researchers have designed a pure capped mRNA vaccine which has shown a better protein production in the immune system.
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NewsEnzyme substrate mutations promote tumour growth
Using a newly developed algorithm and a validation study, US researchers find that cancer hijacks a class of enzyme mutations to fuel tumorigenesis.
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NewsGenome-edited iPSCs show promise for treating Fabry Disease
Japanese researchers successfully engineered iPSCs to secrete a modified enzyme, mNAGA, and restored enzyme activity in vitro and in a mouse model, opening new avenues for regenerative medicine for conditions such as Fabry Disease.
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NewsNovel hydrogel brings hope for infertility and fertility challenges
South Korean researchers have developed a hydrogel using a uterus-derived decellularised extracellular matrix, bringing hope for those challenged with infertility.