All Organoids articles – Page 6
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ArticleStreamlining the path from lab to market with 3D bioprinting
In this Q&A, Dr Vidmantas Šakalys, CEO of Vital3D, provides insights into the potential of 3D bioprinting to revolutionise the traditional drug development process, facilitating more accurate models and limiting the use of animal testing.
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WebinarNeurological disorders: organoids for early drug discovery
Join us for this webinar as we explore the role of organoids in advancing treatment of neurological disorders. Organoids, miniature 3D models of human organs, are at the forefront of neuroscience research, offering insights into the complexities of the human brain. In this webinar, esteemed experts will explore the latest ...
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NewsBrain organoids: essential ethical investigation
The potential for brain organoids to develop consciousness is a key issue in neuroscience, which has prompted new ethical considerations.
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ArticleColon cancer: distinct transcriptional programmes identified
Researchers elucidate the significant role of CDX2 in regulating stemness and differentiation, particularly in the proximal colon’s epithelial cells. This research encourages new combinations of existing drugs, that inhibit both the BRAF and KRAS genes, to be explored.
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ArticleModelling pregestational diabetes-induced congenital heart disease
Using an advanced human heart organoid system, researchers found the contributing factors to the condition and possible therapeutic compounds.
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NewsOrganoid drug testing predicts bowel cancer treatment response
A new study proves that organoid drug testing is highly accurate at predicting effective treatments and finds a novel therapeutic option.
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ArticleMechanisms underlying pioneer TF-mediated gene repression
Researchers have made surprising and important findings that may influence organoid and cell reprogramming studies.
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WhitepapereBook: Modern Microscopy in Cancer Research
Explore the history and trends of microscopy in cancer research and discover the latest cancer imaging solutions and techniques in this eBook.
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News
Neurodevelopmental defects seen in mini-brains with ANG mutation
Researchers found that ANG in its mutated form slows stem cell differentiation, resulting in neurodevelopmental defects in adult nerve cells.
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ArticleBiological robots: a new therapeutic tool
Anthrobots derived from human tracheal cells could perform therapeutic work without initiating an immune response.
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WhitepaperArticle: Tips and Tricks for Leveraging Advanced Flow Cytometry
Tips and tricks for fully leveraging Advanced Flow Cytometry.
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NewsModel for spinal muscular atrophy using human iPSCs
A 2D neuromuscular junction model enables high-throughput screening to discover new treatments for neuromuscular diseases.
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ArticleThe first multi-chamber heart organoids developed
The first multi-chamber cardioids derived from hiPSCs have enabled scientists to investigate heart development and defects.
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NewsNew organoid model of neuroendocrine tumours developed
NETs require epidermal growth factor to grow, meaning that inhibiting EGF receptors could treat these types of tumours.
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ArticleNew gene found plays essential role in stem cell differentiation
Intestinal organoids allowed researchers to understand how Rnf43 and Daam1 influence the balance of stem cell renewal and differentiation.
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NewsNew colon organoids better resemble both healthy and diseased colons
Researchers have developed organoids with naturally occurring early-stage immune cells, which could lead to effective personalised treatment.
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NewsIncorporating microglia into brain organoids
iPS-cell-derived microglia in brain organoids have enabled scientists to understand early brain development and microglia-associated disease.
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ArticleBreaking new ground in endometriosis treatment
Endometriosis is a debilitating condition that affects millions of women worldwide, causing chronic pain, infertility, and a host of other distressing symptoms. Current treatments offer limited relief, but they do not address the cause of the disease. Professor Hugo Vankelecom, at the helm of the CurE-me project, is on a ...
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ArticleHuman organoid research offers insights into gut cell differentiation
How stem cells become enteroendocrine cells using gut organoids could have positive implications for many gastrointestinal diseases.
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NewsNew understanding of early breast cancer development
Mammary organoid cultures show the effects of BRCA2 mutations on breast tissue cells, increasing the likelihood of early, targeted treatment.