All Drug Discovery articles – Page 26
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Article
Natural killer cells: Looking good for cancer therapy
The suitability of NK cells for cancer therapy has been challenged by some investor and business interests because of limited efficacy data, but is this belief at the present stage of development of the immune therapy field?
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ArticleBreaking down barriers across the DMTA cycle
In this article, David Bardsley, Commercial Director, and Nick Foster, Vice President of Discovery CRO at Cresset, explore the challenges that occur when approaching drug discovery in silos and how harnessing advances in technology can help to overcome them.
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ArticleThe power of combinations in blood cancers
Haematology research is a cradle of innovation, with many firsts in therapeutic approaches utilising the latest technology for the treatment of blood cancers. Anas Younes, Senior Vice President, Head of Haematology Oncology Research and Development at AstraZeneca, envisions a future where potential cures are within reach for more blood cancers ...
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ArticleCancer drug discovery: protein-ligand interactions
Dr Rob van Montfort, a leading researcher at the Centre for Cancer Drug Discovery (CCDD) within The Institute of Cancer Research, London, is at the forefront of cancer drug discovery. Focusing on protein-ligand interactions, his work utilises structural biology and biochemical methods to help the discovery of novel small-molecule drugs ...
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NewsNew small molecule blocks immune response signalling pathway
A new small molecule has great promise for the treatment of autoimmune diseases by inhibiting the proinflammatory signalling pathway.
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NewsKey epitope can trigger tumour cell death
An epitope on CD95 receptor causes tumour cells to self-destruct and may prolong benefits of CAR T-cell therapy for solid tumours.
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ArticleEmotional scars: stigma with female adult acne
New research presented at the European Academy of Dermatology and Venereology (EADV) Congress 2023 in Berlin, Germany, has highlighted a previously underestimated aspect of acne's impact on individuals: its profound influence on social perception.
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ArticleCould scratching nerve cells be the itch solution?
The sensation of itch is something everyone has experienced at some point in their lives. It's a natural response to various irritants, from insect bites to dry skin. But what happens when the urge to itch becomes relentless, causing discomfort and, in some cases, serious health problems?
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ArticleThe inner workings of environmental bacterium
Researchers have achieved profound insights into the inner workings of a prevalent environmental bacterium.
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ArticleSino Biological: new US centre for bioprocessing
Sino Biological are pleased to announce the formal opening of its new center for Bioprocessing (C4B) in Houston, Texas USA at Levit Green, adjacent to the world-renowned Texas Medical Center.
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ArticleAntibody-drug conjugates payloads: then, now and next
Dr Nicolas Camper at CDMO Abzena and colleagues offer insight into the landscape of antibody-drug conjugates and how the therapy is evolving.
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Article
Artificial intelligence model revolutionises breast cancer surgery
Artificial intelligence (AI) and machine learning (ML) have been gaining significant attention lately, primarily in discussions about their responsible utilisation. However, these technologies possess a wide spectrum of practical applications, ranging from predicting natural disasters to addressing social disparities. Now, AI is making its mark in the field of cancer ...
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WebinarUnlocking protein potential: liquid handling solutions for drug discovery
Watch this webinar to learn how PROTACs are revolutionising drug discovery, and the critical role protein purification plays in the production of therapeutic proteins.
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ArticleWomen in Stem with Dr Emily Leproust
This September edition of our Women in Stem series spotlights Dr Emily Leproust, CEO of Twist Bioscience. Dr Leproust began her STEM journey from a background in chemistry, eventually leading her to the forefront of DNA synthesis technology. She co-founded Twist Bioscience in 2013, now a thriving company reporting substantial ...
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News
Novel approach to overcome resistance to cancer drugs
Researchers at the University of Queensland have discovered a promising drug target capable of addressing drug resistance and preventing tumour regrowth in cancer patients.
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ArticleHow organoids can redefine pre-clinical research
Organoids, lab-grown 3D structures that mimic human organs, are redefining preclinical research through bypassing the ethical and practical limitations of animal models. Technological advancements in organoid research, including automation and improved analytical tools, promise to unlock new possibilities by streamlining the application of these 3D structures to enhance drug development ...
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ArticlePossible adulticidal drugs for Onchocerca volvulus
This article discusses the need for adulticidal drugs to treat Onchocerca volvulus infections, a parasite causing onchocerciasis (river blindness), as the current treatment with ivermectin and surgery presents challenges for affected communities. It highlights research findings on the potential of analgesic medicines to target adult worms and emphasises the importance ...
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ArticleHow the AI revolution can accelerate early drug discovery
Rob Scoffin and Matthew Habgood from solutions provider Cresset look to the future of drug discovery and the roles that artificial intelligence and machine learning could play.
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ArticleAddressing increasingly resistant drugs by infectious agents
Infectious agents' drug resistance is a complex challenge affecting survival. Understanding their mechanisms in vectors, the potential of plant-derived treatments, and roles of nucleic acids and biochemical compounds is crucial for effective therapy, requiring collaborative international research through the One Health Initiative.