All In Vivo Testing articles – Page 10
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NewsBlastoids enable greater understanding of human gastrulation
Stem-cell based blastocyst models have enabled scientists to redefine the molecular signature and timing of the onset of gastrulation.
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ArticleDeveloping an mRNA therapy for Duchenne muscular dystrophy
In this Q&A, Aki Ko, CEO and co-founder of Elixirgen Therapeutics, elucidates how their new mRNA technology could potentially restore muscle function in those suffering from Duchenne muscular dystrophy.
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NewsP47 suppresses metastasis of HER2-positive breast cancer
Results from an in vivo CRISPR knockout screen, targeting genes involved in autophagy, could lead to new therapies.
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ArticleScalable precision design targeting complex product profiles
We had the privilege of speaking to Dr Víctor Sebastián Pérez, Associate Director of Computational Drug Design, following his presentation at ELRIG UK 2023. He shares his insights into how Exscientia is using AI to design drug candidates for cancer treatment.
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NewsDOP-targeted therapies could exert significant anxiolytic effects
Researchers have uncovered the role of the PL-BLA neuronal axis and its potential function in DOP-mediated anxiolytic effects.
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News
Improved CAR T-cell immunotherapy for acute myeloid leukaemia
Researchers have created dual-targeted CARs, which performed better than single-targeted CARs in both in vivo and in vitro experiments.
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NewsReplacing the PKP2 gene prolongs survival in ARVC patients
The new study suggests that this gene therapy method may combat ARVC in both early and more advanced stages of the condition.
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WhitepaperConsistent, functional lower motor neurons from iPSCs
How pure consistent and functional lower motor neurons can be precision reprogrammed from iPSCs for motor neuron disease research and drug discovery.
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NewsImproved targeted ocular spectroscopy for better diagnosis
In vitro and in vivo experiments highlight the advantages of a new targeted spectroscopy system for many eye diseases.
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NewsNew potential drug target is discovered for diabetes treatment
Researchers found heightened SCAN enzyme activity in humans and mice with diabetes results in excessive nitric oxide on insulin receptors.
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NewsEnzyme-activated fluorescent probes could revolutionise healthcare
Advancements in enzyme-activated near-infrared fluorescent probes hold promise for evaluating responses to enzyme-targeting therapies.
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NewsLimiting diaphragm atrophy in intensive care
Mitochondrial fragmentation mechanism that can cause ventilator-induced diaphragm dysfunction (VIDD) found, and a therapeutic to mitigate it.
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NewsNutrient programmes immune cells to battle infection and cancer
Research suggests immune and non-immune cells can be reprogrammed by changing how nutrients are used.
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NewsEngineered immune cells for improved cancer defence
A collaborative team has uncovered a method to extend the functionality of CAR-T cells.
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NewsNovel targets identified for treatment of schistosomiasis
Researchers from Brazil discovered that survival of the parasitic worm that cause the disease schistosomiasis, depends on expression of a specific type of RNA. In animal trials, inhibition of the molecule interrupted the infection.
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ArticleNavigating the challenges and opportunities of AI in drug development and personalised medicine
This article is the second part of Drug Target Review’s Izzy Wood’s discussion with Olivia Cavlan, Chief Corporate Development and Strategy Officer at Alchemab Therapeutics Ltd, exploring the role of AI in target discovery, its applications in personalised medicine, and the evolving landscape of pharmaceutical development.
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NewsGenome-edited iPSCs show promise for treating Fabry Disease
Japanese researchers successfully engineered iPSCs to secrete a modified enzyme, mNAGA, and restored enzyme activity in vitro and in a mouse model, opening new avenues for regenerative medicine for conditions such as Fabry Disease.
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NewsA new way to visualise sensory neurons
US researchers have uncovered a novel method using a tool used to visualise ion channels in mechanosensory neurons.
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NewsPredicting cerebrovascular diseases with retinal imaging
New imaging approach reveals that changes in retinal microcirculation may indicate cerebrovascular diseases that involve reduced blood flow.
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Articleebook: Advances In Cell Imaging and Retrieval
Unleash the power of drug discovery with this FREE ebook supported by Sartorius! Explore the limitless potential of CRISPR applications and single cell sequencing for drug discovery. Access exclusive insights from industry leaders and stay ahead of the curve with the latest trends. Don't miss out on this opportunity to ...