All Analytical Techniques articles – Page 3
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NewsNew study identifies genetic weakness in deadly Candida auris fungus
Scientists at the University of Exeter have discovered a genetic process in the deadly hospital fungus Candida auris, which could help to develop new treatments.
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NewsTiny RNA molecule helps viruses hijack bacterial cells
Scientists have discovered a hidden RNA ‘switch’ used by bacteriophages to hijack bacterial cells, revealing a new layer of viral control that could help advance phage therapy and efforts to combat antibiotic-resistant infections.
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NewsParkinson’s: new study rethinks dopamine’s role in movement
A new study is challenging long-held beliefs about dopamine’s role in movement, revealing new insights into how Parkinson’s disease treatments work and pointing towards more targeted future therapies.
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ArticleBuilding better biologics and a stronger future for women in STEM
Great biologics don’t happen by chance, and neither do great STEM careers. Dr Lidia Serina shares the lessons behind both.
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ArticleThe future of obesity drugs starts in preclinical discovery
Progress in preclinical models and biomarker science is improving early-stage obesity drug development. This article outlines the emerging targets and technologies behind this shift.
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NewsInhibiting DDR1 pathway helps breach pancreatic cancer’s drug barrier
Scientists in Japan have identified a way to weaken the dense fibrotic barrier that prevents drugs from penetrating pancreatic tumours – a promising new strategy that could improve treatment for pancreatic cancer.
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ArticleProtein folding interference: a new path to hard-to-drug targets
Protein folding interference offers access to targets long considered unreachable by traditional drug discovery. By acting on transient folding intermediates, this approach presents a new opportunity to eliminate disease-driving proteins.
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NewsNew organ-on-a-chip models ageing immune response for cancer vaccines
Scientists have developed an organ-on-a-chip platform that replicates age-related immune decline, offering a long-missing tool for testing cancer vaccines in older adults.
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ArticleRNA that knows where to go: the rise of targeted delivery
What if RNA medicines could be guided directly to tumours, sparing healthy tissue and reducing side effects? Advances in targeted delivery are bringing that vision closer to reality.
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NewsFibulin-5 linked to early detection of liver fibrosis
Researchers in Japan have identified a promising blood-based marker that could enable faster, simpler and more accurate detection of liver fibrosis.
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NewsEstrone hormone linked to deadly breast cancer in obese women
A new analysis has identified the hormone estrone as a major driver of aggressive breast cancer in post-menopausal women with obesity, meaning that weight-loss drugs could help improve treatment outcomes.
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NewsBits2Bonds: AI system accelerates discovery of RNA delivery polymers
Researchers at LMU Munich have developed Bits2Bonds, the first platform to fuse molecular simulations with machine learning – accelerating the discovery of polymer carriers for therapeutic RNA.
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NewsAutomated lung organoids to speed up new drug development
Scientists have developed an automated method to grow lung organoids, with the hope of speeding up drug testing, reducing reliance on animal models and helping to develop new personalised treatments.
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ArticleThe partnership changing the pace of radiopharmaceutical development
A new collaboration between Crown Bioscience and Medicines Discovery Catapult is bringing advanced tumour models together with world-class imaging and radiochemistry to accelerate the development of next-generation radiopharmaceuticals.
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NewsResearchers identify new drug site on epilepsy target SV2A
A team led by St. Jude Children’s Research Hospital and UT Southwestern has mapped how key anti-epilepsy drugs latch onto their neural target, SV2A.
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NewsAI powers discovery of new CBLB inhibitor ISM3830
Insilico Medicine has announced ISM3830, an AI-designed CBLB inhibitor that has demonstrated promising preclinical results.
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ArticleRedesigning paclitaxel: expanding the therapeutic window through oral delivery
The potent chemotherapy drug paclitaxel is widely employed for various cancers despite toxicity and efficacy challenges. Maite Agüeros reveals how novel nanoparticle technology has enabled oral delivery of the drug – showing promising signs of improved tolerability and treatment success.
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NewsKidney fibrosis linked to overactive Hippo signalling pathway
Scientists have used human stem cell–derived kidney organoids to uncover how abnormal Hippo signalling drives scarring in nephronophthisis, a rare genetic kidney disease.
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NewsWhy TIGIT cancer therapies work in monkeys but not humans
A new study reveals that TIGIT, a key immune checkpoint targeted by cancer drugs, behaves differently in rhesus macaques and humans, suggesting current animal tests may be misleading drug development.
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NewsKinase inhibitors shown to accelerate protein breakdown
A new study has revealed that many kinase inhibitors – key drugs used in cancer and other diseases – also trigger the accelerated degradation of their target proteins, which could inform future therapies.