New RNA sequencing method reveals molecular structures at single-molecule resolution

Drug Target Review2026-05-15T09:31:00

A*STAR scientists have developed sm-PORE-cupine, a nanopore-based sequencing method that maps individual RNA structures at single-molecule resolution.

The technology combines chemical labelling with direct RNA sequencing to reveal how structural variations influence protein production, RNA stability and disease pathogenesis, with potential applications in antiviral development and precision therapeutics.

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