All Drug Discovery articles
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NewsDNA enhancer switch drives androgen receptor breast cancer suppression
A small regulatory DNA element called HRRINT3 has been found to play a critical role in enabling the androgen receptor to suppress cell growth in oestrogen receptor-positive breast cancer, pointing towards new therapeutic strategies for patients with advanced disease.
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Company profileLight-powered reaction converts sulfonamides into drug discovery building blocks
A light-driven chemical reaction developed at Florida State University can strip sulfur atoms from sulfonamides to produce anilines, offering a new route to repurpose previously intractable compounds for drug discovery.
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ArticleHow asymmetric binding affinity enables reversible IL-12 switches
Stronger binding isn’t always better. Dr Teresa Barata of FairJourney Bio explains how researchers engineered a dual-specificity antibody switch designed to control IL-12 activity in tumours.
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NewsFramework proposed to advance plant-derived anti-inflammatory drug discovery
A review led by researchers at the Naval Medical University proposes a structured framework for evaluating plant-derived anti-inflammatory compounds, warning that pathway inhibition alone is insufficient evidence of direct molecular target engagement.
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ArticleWhat tissue accumulation can reveal about oligonucleotide safety
Oligonucleotides can remain in tissues long after disappearing from circulation, but does accumulation necessarily indicate toxicity? Dr Tina Rogers examines the evidence needed to interpret preclinical safety findings.
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NewsZinc finger protein found to suppress amyloid-beta aggregation in Alzheimer’s
A protein best known for regulating genes has been shown to suppress amyloid-beta aggregation and reduce aggregate toxicity in a transgenic mouse model of Alzheimer’s disease.
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NewsTriptolide plant compound could improve response to epigenetic cancer drugs
Researchers at Johns Hopkins have identified a natural plant compound capable of blocking an enzyme that degrades DNA methyltransferase inhibitors, offering a potential strategy to overcome resistance to epigenetic cancer therapies.
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ArticleStrong binding isn’t enough – why cellular target engagement matters
Promising compounds don’t always engage their targets in living cells. At ELRIG Drug Discovery 2026, Dr Joshua Sopp of Promega discusses why earlier cellular testing matters and how BRETSA could help researchers investigate new drug targets.
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ReportLab Automation 2026: Inside the labs making drug discovery faster and more reliable
Six scientists and industry experts discuss the challenges of automating drug discovery, from improving screening reliability and reproducibility to developing more autonomous laboratories.
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NewsNovel RNA-protein interactions reveal conserved SARS-CoV-2 antiviral targets
A new study has mapped previously unknown RNA-protein interactions across the SARS-CoV-2 genome, identifying conserved sites involving RdRp and the nucleocapsid protein as potential antiviral drug targets less susceptible to mutational escape.
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ArticleHow AI is changing the way therapeutic antibodies are designed
What if researchers could design therapeutic antibodies instead of relying on screening millions of candidates? Generative AI is making this increasingly possible, offering new ways to tackle challenging targets.
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NewsYAP/TAZ protein hyperactivity linked to immune evasion via PD-L2 upregulation
Researchers have identified a mechanism by which overactive YAP and TAZ proteins may simultaneously increase cancer cell visibility to the immune system and shield tumours from T-cell attack.
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ArticleVirtual cells vs experimental models: which can you trust?
How reliable are AI virtual cells compared with experimental models? We examine what each can predict or measure, the evidence behind their reliability and their role in early drug discovery.
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ArticleWhy reagent selection belongs inside assay design
High affinity is often a priority when selecting reagents, but does it guarantee better assay performance? Discover why binding kinetics and matrix selectivity matter when developing custom reagents for challenging targets.
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InterviewHow multiomics can strengthen drug target discovery
How can multiomics help researchers identify more promising drug targets? Dr Shi-qi An explores how combining molecular data can reveal therapeutic vulnerabilities and mechanisms of drug resistance.
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NewsSMVT brain transporter protein opens new drug delivery route
Researchers have identified a transporter protein that could enable creatine derivatives and other therapeutic compounds to cross the blood-brain barrier, with potential implications for treating Creatine Transporter Deficiency Syndrome and other neurological disorders.
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NewsDual-therapy approach targets TNBC energy supply in preclinical study
A combination of a CD276-targeting antibody-drug conjugate and mitochondria-disrupting gene therapy has demonstrated anti-tumour activity in preclinical models of metastatic triple-negative breast cancer.
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NewsImmune profiling could help tailor treatment for primary biliary cholangitis
A new review of primary biliary cholangitis reveals how interactions between bile duct epithelial cells and immune populations sustain chronic inflammation, and explores whether mapping individual disease mechanisms could guide more targeted therapies.
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NewsHidden bacterial compounds reveal potential cancer drug leads
Researchers have discovered a new family of bacterial natural products that bind the cancer-associated enzyme AKR1C3, revealing potential starting points for drug discovery.
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NewsWhy aptamer cancer therapies are struggling to reach the clinic
Aptamers can recognise cancer-associated targets and deliver drugs directly to tumour cells. So why have so few reached the clinic? A new review examines the barriers to their development.