All Synthetic Biology articles
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NewsSynthetic organiser cells enhance kidney organoid reproducibility and accuracy
Scientists at the University of Southern California have engineered synthetic organiser cells that produce localised Wnt signals to guide kidney organoid development, yielding more reproducible, physiologically accurate structures and revealing a previously unrecognised developmental axis in the human kidney.
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NewsStreptomyces antibiotic ‘megacluster’ targets biotin to combat drug-resistant infections
Researchers at McMaster University have identified an unprecedented antibiotic ‘megacluster’ in Streptomyces bacteria, harbouring four co-located gene clusters that produce compounds collectively targeting bacterial biotin biosynthesis, uptake and utilisation — with two proving effective against multidrug-resistant E. coli in animal models.
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NewsMineralised DNA hydrogel accelerates bone repair in preclinical studies
A mineralised DNA hydrogel has demonstrated accelerated bone repair and improved tissue mineralisation in preclinical studies, offering a potential new approach to treating difficult bone defects through combined immune regulation and sustained regeneration.
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NewsDNA ‘needle’ bypasses cellular defences to deliver therapeutics
A microscopic DNA nanostructure inspired by bacteriophages can deliver therapeutic molecules directly into cells whilst evading endosomal traps that typically render treatments ineffective. The virus-inspired platform, demonstrated in breast cancer cells, could address the longstanding challenge that only one per cent of oligonucleotide therapeutics reach their cellular targets.
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NewsDNA-based system delivers targeted cancer drugs via biomarker logic
Researchers at the University of Geneva have developed a DNA-based drug delivery platform that uses molecular logic gates to identify cancer cells through dual biomarker recognition. The system activates cytotoxic agents only when both tumour markers are present, offering enhanced specificity over current antibody–drug conjugates while enabling deeper tissue penetration and multi-drug combinations.
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NewsControlling cellular noise may stop cancer and bacterial relapse
Scientists have developed a new mathematical ‘Noise Controller’ that can stabilise random cellular fluctuations, offering a potential breakthrough in preventing cancer recurrence and antibiotic resistance.
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ArticleGene therapies that listen and respond: the power of RNA regulation
Most gene therapies rely on static DNA promoters to control gene activity, but nature uses far more sophisticated tools. Dr Matthew Dale explores how harnessing RNA-level control could enable treatments that sense and respond in real time, offering unprecedented precision and safety.
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NewsAI just made protein design smarter and faster
Meet the AI tool that creates proteins that fold better, bind tighter and perform more reliably. Find out why it matters for next-generation medicines.
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ArticleSynthetic promoters enhance gene therapy precision
Discover how Chromatin Bioscience’s synthetic promoters are transforming gene therapy by enhancing precision, boosting safety and improving manufacturing efficiency.