Streptomyces antibiotic ‘megacluster’ targets biotin to combat drug-resistant infections
Researchers at McMaster University have identified an unprecedented antibiotic ‘megacluster’ in Streptomyces bacteria, harbouring four co-located gene clusters that produce compounds collectively targeting bacterial biotin biosynthesis, uptake and utilisation — with two proving effective against multidrug-resistant E. coli in animal models.
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